PURPOSE: To assess metamorphopsia in patients with macular telangiectasia (MacTel) type 2. METHODS: In a prospective observational cohort study, 40 eyes of 20 patients with MacTel type 2 were investigated by funduscopy, fluorescein angiography, optical coherence tomography and microperimetry. Metamorphopsia was assessed using Amsler grids following a standard protocol and standardized questionnaire. RESULTS: Metamorphopsia was present in 30 (83%) out of 36 nonproliferative eyes and in all four eyes with neovascular membranes. In the 30 nonproliferative eyes with distortions, metamorphopsia was always present in the nasal quadrant of the central visual field. Distortions were most pronounced in the nasal and lower quadrant in 70 and 30%, respectively. Three nonproliferative eyes with a very early and three eyes with a late disease stage did not perceive metamorphopsia. The degree of distortions was often but not necessarily correlated with the degree of leakage. Metamorphopsia was present in five out of eight eyes with normal sensitivity in microperimetry testing. Detection of scotoma by Amsler grid testing was poor. CONCLUSION: Metamorphopsia is a frequent clinical symptom in MacTel type 2 even in the absence of neovascularization. Since macular thickness was within normal limits in such eyes, extensive swelling or distortion of the neurosensory retina would not account for metamorphopsia in contrast to other macular diseases such as age-related macular degeneration or idiopathic epiretinal membranes.
PURPOSE: To assess metamorphopsia in patients with macular telangiectasia (MacTel) type 2. METHODS: In a prospective observational cohort study, 40 eyes of 20 patients with MacTel type 2 were investigated by funduscopy, fluorescein angiography, optical coherence tomography and microperimetry. Metamorphopsia was assessed using Amsler grids following a standard protocol and standardized questionnaire. RESULTS:Metamorphopsia was present in 30 (83%) out of 36 nonproliferative eyes and in all four eyes with neovascular membranes. In the 30 nonproliferative eyes with distortions, metamorphopsia was always present in the nasal quadrant of the central visual field. Distortions were most pronounced in the nasal and lower quadrant in 70 and 30%, respectively. Three nonproliferative eyes with a very early and three eyes with a late disease stage did not perceive metamorphopsia. The degree of distortions was often but not necessarily correlated with the degree of leakage. Metamorphopsia was present in five out of eight eyes with normal sensitivity in microperimetry testing. Detection of scotoma by Amsler grid testing was poor. CONCLUSION:Metamorphopsia is a frequent clinical symptom in MacTel type 2 even in the absence of neovascularization. Since macular thickness was within normal limits in such eyes, extensive swelling or distortion of the neurosensory retina would not account for metamorphopsia in contrast to other macular diseases such as age-related macular degeneration or idiopathic epiretinal membranes.
Authors: Lelia A Paunescu; Tony H Ko; Jay S Duker; Annie Chan; Wolfgang Drexler; Joel S Schuman; James G Fujimoto Journal: Ophthalmology Date: 2005-12-15 Impact factor: 12.079
Authors: Robert P Finger; Peter Charbel Issa; Rolf Fimmers; Frank G Holz; Gary S Rubin; Hendrik P N Scholl Journal: Invest Ophthalmol Vis Sci Date: 2008-11-07 Impact factor: 4.799
Authors: Gildo Y Fujii; Eugene de Juan; Janet Sunness; Mark S Humayun; Dante J Pieramici; Tom S Chang Journal: Ophthalmology Date: 2002-09 Impact factor: 12.079
Authors: Steffen Schmitz-Valckenberg; Kristie Fan; Alex Nugent; Gary S Rubin; Tunde Peto; Adnan Tufail; Cathy Egan; Alan C Bird; Fred W Fitzke Journal: Arch Ophthalmol Date: 2008-03
Authors: Annal D Meleth; Brian C Toy; Divya Nigam; Elvira Agrón; Robert P Murphy; Emily Y Chew; Wai T Wong Journal: Retina Date: 2013-04 Impact factor: 4.256
Authors: Peter Charbel Issa; Mark C Gillies; Emily Y Chew; Alan C Bird; Tjebo F C Heeren; Tunde Peto; Frank G Holz; Hendrik P N Scholl Journal: Prog Retin Eye Res Date: 2012-12-03 Impact factor: 21.198
Authors: Nancy L Parmalee; Carl Schubert; Joanna E Merriam; Kaija Allikmets; Alan C Bird; Mark C Gillies; Tunde Peto; Maria Figueroa; Martin Friedlander; Marcus Fruttiger; John Greenwood; Stephen E Moss; Lois E H Smith; Carmel Toomes; Chris F Inglehearn; Rando Allikmets Journal: Mol Vis Date: 2010-12-14 Impact factor: 2.711
Authors: Nancy L Parmalee; Carl Schubert; Maria Figueroa; Alan C Bird; Tunde Peto; Mark C Gillies; Paul S Bernstein; Krzysztof Kiryluk; Joseph D Terwilliger; Rando Allikmets Journal: PLoS One Date: 2012-08-31 Impact factor: 3.752