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Literature DB >> 19710318

DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains.

Christina H Liu¹, Jia Q Ren, Jinsheng Yang, Charng-ming Liu, Joseph B Mandeville, Bruce R Rosen, Pradeep G Bhide, Yuchio Yanagawa, Philip K Liu.

Abstract

We designed phosphorothioate-modified DNA probes linked to superparamagnetic iron oxide nanoparticles (SPION) for in vivo magnetic resonance imaging (MRI) of fosB and Delta fosB mRNA after amphetamine (AMPH) exposure in mice. Specificity of both the fosB and Delta fosB probes was verified by in vitro reverse transcriptase-PCR amplification to a single fragment of total cDNA obtained from acutely AMPH-exposed mouse brains. We confirmed time-dependent uptake and retention profiles of both probes in neurons of GAD67-green fluorescent protein knock-in mice. MRI signal of SPION-labeled fosB probe delivered via intracerebroventricular route was elevated in both acutely and chronically AMPH-exposed mice; the signal was suppressed by dopaminergic receptor antagonist pretreatment. SPION-labeled Delta fosB probe signal elevation occurred only in chronically AMPH-exposed mice. The in vivo target specificity of these probes permits reliable MRI visualization of AMPH-induced differential elevations of fosB and Delta fosB mRNA in living brains.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19710318 PMCID： PMC2746375 DOI： 10.1523/JNEUROSCI.2167-09.2009

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

43 in total

1. Noninvasive delivery of gene targeting probes to live brains for transcription MRI.

Authors: Christina H Liu; Zerong You; JiaQian Ren; Young R Kim; Katharina Eikermann-Haerter; Philip K Liu
Journal: FASEB J Date: 2007-11-20 Impact factor: 5.191

2. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.

Authors: B T Hope; H E Nye; M B Kelz; D W Self; M J Iadarola; Y Nakabeppu; R S Duman; E J Nestler
Journal: Neuron Date: 1994-11 Impact factor: 17.173

3. Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats.

Authors: P E Paulson; D M Camp; T E Robinson
Journal: Psychopharmacology (Berl) Date: 1991 Impact factor: 4.530

4. Acute and repeated systemic amphetamine administration: effects on extracellular glutamate, aspartate, and serine levels in rat ventral tegmental area and nucleus accumbens.

Authors: C J Xue; J P Ng; Y Li; M E Wolf
Journal: J Neurochem Date: 1996-07 Impact factor: 5.372

5. Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP.

Authors: Peter Gass; Alexander Fleischmann; Oivind Hvalby; Vidar Jensen; Christiane Zacher; Tatyana Strekalova; Ane Kvello; Erwin F Wagner; Rolf Sprengel
Journal: Brain Res Mol Brain Res Date: 2004-11-04

6. Diffusion-weighted magnetic resonance imaging reversal by gene knockdown of matrix metalloproteinase-9 activities in live animal brains.

Authors: Christina H Liu; Zerong You; Charng-Ming Liu; Young R Kim; Michael J Whalen; Bruce R Rosen; Philip K Liu
Journal: J Neurosci Date: 2009-03-18 Impact factor: 6.167

7. Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA.

Authors: P K Liu; A Salminen; Y Y He; M H Jiang; J J Xue; J S Liu; C Y Hsu
Journal: Ann Neurol Date: 1994-10 Impact factor: 10.422

8. Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS.

Authors: Alexander Fleischmann; Oivind Hvalby; Vidar Jensen; Tatyana Strekalova; Christiane Zacher; Liliana E Layer; Ane Kvello; Markus Reschke; Rainer Spanagel; Rolf Sprengel; Erwin F Wagner; Peter Gass
Journal: J Neurosci Date: 2003-10-08 Impact factor: 6.167

9. Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species.

Authors: Miles Johnston; Andrei Zakharov; Christina Papaiconomou; Giselle Salmasi; Dianna Armstrong
Journal: Cerebrospinal Fluid Res Date: 2004-12-10

10. Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels.

Authors: T P Giordano; S S Satpute; J Striessnig; B E Kosofsky; A M Rajadhyaksha
Journal: J Neurochem Date: 2006-10-05 Impact factor: 5.372

15 in total

DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains.

1. Noninvasive delivery of gene targeting probes to live brains for transcription MRI.

2. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.

3. Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats.

4. Acute and repeated systemic amphetamine administration: effects on extracellular glutamate, aspartate, and serine levels in rat ventral tegmental area and nucleus accumbens.

5. Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP.

6. Diffusion-weighted magnetic resonance imaging reversal by gene knockdown of matrix metalloproteinase-9 activities in live animal brains.

7. Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA.

8. Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS.

9. Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species.

10. Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels.

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