BACKGROUND: Weight loss leads to reduced resting energy expenditure (REE) independent of fat-free mass (FFM) and fat mass (FM) loss, but the effect of changes in FFM composition is unclear. OBJECTIVE: We hypothesized that a decrease in REE adjusted for FFM with weight loss would be partly explained by a disproportionate loss in the high metabolic activity component of FFM. DESIGN: Forty-five overweight and obese women [body mass index (in kg/m(2)): 28.7-46.8] aged 22-46 y followed a low-calorie diet for 12.7 +/- 2.2 wk. Body composition was measured by magnetic resonance imaging, dual-energy X-ray absorptiometry, and a 4-compartment model. REE measured by indirect calorimetry (REEm) was compared with REE calculated from detailed body-composition analysis (REEc) by using specific organ metabolic rates (ie, organ REE/mass). RESULTS: Weight loss was 9.5 +/- 3.4 kg (8.0 +/- 2.9 kg FM and 1.5 +/- 3.1 kg FFM). Decreases in REE (-8%), free triiodothyronine concentrations (-8%), muscle (-3%), heart (-5%), liver (-4%), and kidney mass (-6%) were observed (all P < 0.05). Relative loss in organ mass was significantly higher (P < 0.01) than was the change in low metabolically active FFM components (muscle, bone, and residual mass). After weight loss, REEm - REEc decreased from 0.24 +/- 0.58 to 0.01 +/- 0.44 MJ/d (P = 0.01) and correlated with the decrease in free triiodothyronine concentrations (r = 0.33, P < 0.05). Women with high adaptive thermogenesis (defined as REEm - REEc < -0.17 MJ/d) had less weight loss and conserved FFM, liver, and kidney mass. CONCLUSIONS: After weight loss, almost 50% of the decrease in REEm was explained by losses in FFM and FM. The variability in REEm explained by body composition increased to 60% by also considering the weight of individual organs.
BACKGROUND:Weight loss leads to reduced resting energy expenditure (REE) independent of fat-free mass (FFM) and fat mass (FM) loss, but the effect of changes in FFM composition is unclear. OBJECTIVE: We hypothesized that a decrease in REE adjusted for FFM with weight loss would be partly explained by a disproportionate loss in the high metabolic activity component of FFM. DESIGN: Forty-five overweight and obesewomen [body mass index (in kg/m(2)): 28.7-46.8] aged 22-46 y followed a low-calorie diet for 12.7 +/- 2.2 wk. Body composition was measured by magnetic resonance imaging, dual-energy X-ray absorptiometry, and a 4-compartment model. REE measured by indirect calorimetry (REEm) was compared with REE calculated from detailed body-composition analysis (REEc) by using specific organ metabolic rates (ie, organ REE/mass). RESULTS:Weight loss was 9.5 +/- 3.4 kg (8.0 +/- 2.9 kg FM and 1.5 +/- 3.1 kg FFM). Decreases in REE (-8%), free triiodothyronine concentrations (-8%), muscle (-3%), heart (-5%), liver (-4%), and kidney mass (-6%) were observed (all P < 0.05). Relative loss in organ mass was significantly higher (P < 0.01) than was the change in low metabolically active FFM components (muscle, bone, and residual mass). After weight loss, REEm - REEc decreased from 0.24 +/- 0.58 to 0.01 +/- 0.44 MJ/d (P = 0.01) and correlated with the decrease in free triiodothyronine concentrations (r = 0.33, P < 0.05). Women with high adaptive thermogenesis (defined as REEm - REEc < -0.17 MJ/d) had less weight loss and conserved FFM, liver, and kidney mass. CONCLUSIONS: After weight loss, almost 50% of the decrease in REEm was explained by losses in FFM and FM. The variability in REEm explained by body composition increased to 60% by also considering the weight of individual organs.
Authors: Stanley Heshka; Thaisa Lemos; Nerys M Astbury; Elizabeth Widen; Lance Davidson; Bret H Goodpaster; James P DeLany; Gladys W Strain; Alfons Pomp; Anita P Courcoulas; Susan Lin; Isaiah Janumala; Wen Yu; Patrick Kang; John C Thornton; Dympna Gallagher Journal: Obes Surg Date: 2020-02 Impact factor: 4.129
Authors: Fernando Lamarca; Mariana Silva Melendez-Araújo; Isabela Porto de Toledo; Eliane Said Dutra; Kênia Mara Baiocchi de Carvalho Journal: Obes Surg Date: 2019-08 Impact factor: 4.129
Authors: Todd M Manini; Thomas W Buford; Donovan J Lott; Krista Vandenborne; Michael J Daniels; Jeffrey D Knaggs; Hetain Patel; Marco Pahor; Michael G Perri; Stephen D Anton Journal: J Gerontol A Biol Sci Med Sci Date: 2013-05-16 Impact factor: 6.053
Authors: S B Heymsfield; C M Peterson; B Bourgeois; D M Thomas; D Gallagher; B Strauss; M J Müller; A Bosy-Westphal Journal: Obes Rev Date: 2018-07-23 Impact factor: 9.213
Authors: Britta Hitze; Christian Hubold; Regina van Dyken; Kristin Schlichting; Hendrik Lehnert; Sonja Entringer; Achim Peters Journal: Front Neuroenergetics Date: 2010-06-09