Literature DB >> 19709623

Location matters: synaptotagmin helps place vesicles near calcium channels.

Benjamin D McNeil1, Ling-Gang Wu.   

Abstract

Positioning releasable vesicles near voltage-gated calcium channels may ensure transmitter release upon calcium influx. Disruption of vesicle positioning may underlie short-term synaptic depression. However, how this positioning is achieved is unclear. In this issue of Neuron, Young and Neher find that synaptotagmin 2 helps to align readily releasable vesicles near calcium channels at nerve terminals.

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Year:  2009        PMID： 19709623      PMCID： PMC4888869          DOI： 10.1016/j.neuron.2009.08.001

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  15 in total

1.  The reduced release probability of releasable vesicles during recovery from short-term synaptic depression.

Authors:  L G Wu; J G Borst
Journal:  Neuron       Date:  1999-08       Impact factor: 17.173

2.  Two modes of fusion pore opening revealed by cell-attached recordings at a synapse.

Authors:  Liming He; Xin-Sheng Wu; Raja Mohan; Ling-Gang Wu
Journal:  Nature       Date:  2006-10-25       Impact factor: 49.962

3.  The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release.

Authors:  Kristian Wadel; Erwin Neher; Takeshi Sakaba
Journal:  Neuron       Date:  2007-02-15       Impact factor: 17.173

4.  Calcium dependence of exo- and endocytotic coupling at a glutamatergic synapse.

Authors:  Nobutake Hosoi; Matthew Holt; Takeshi Sakaba
Journal:  Neuron       Date:  2009-07-30       Impact factor: 17.173

5.  Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor.

Authors:  Samuel M Young; Erwin Neher
Journal:  Neuron       Date:  2009-08-27       Impact factor: 17.173

6.  Intracellular calcium dependence of transmitter release rates at a fast central synapse.

Authors:  R Schneggenburger; E Neher
Journal:  Nature       Date:  2000-08-24       Impact factor: 49.962

7.  Ca(2+) and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal.

Authors:  Xin-Sheng Wu; Benjamin D McNeil; Jianhua Xu; Junmei Fan; Lei Xue; Ernestina Melicoff; Roberto Adachi; Li Bai; Ling-Gang Wu
Journal:  Nat Neurosci       Date:  2009-07-26       Impact factor: 24.884

8.  Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.

Authors:  M Geppert; Y Goda; R E Hammer; C Li; T W Rosahl; C F Stevens; T C Südhof
Journal:  Cell       Date:  1994-11-18       Impact factor: 41.582

9.  Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons.

Authors:  Jun Xu; Tomoyuki Mashimo; Thomas C Südhof
Journal:  Neuron       Date:  2007-05-24       Impact factor: 17.173

10.  The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.

Authors:  Mingshan Xue; Cong Ma; Timothy K Craig; Christian Rosenmund; Josep Rizo
Journal:  Nat Struct Mol Biol       Date:  2008-10-26       Impact factor: 15.369
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  1 in total

1.  Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis.

Authors:  Margarete E Swadzba; Stefanie M Hauck; Hassan Y Naim; Barbara Amann; Cornelia A Deeg
Journal:  PLoS One       Date:  2012-12-07       Impact factor: 3.240
  1 in total

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