Literature DB >> 1970917

Metastasizing neuroendocrine carcinoma of the larynx with calcitonin and somatostatin secretion and CEA production, resembling medullary thyroid carcinoma.

G Smets1, F Warson, M F Dehou, G Storme, R Sacré, S Van Belle, G Somers, W Gepts, G Klöppel.   

Abstract

A 55-year-old man presented with a metastasizing moderately differentiated neuroendocrine carcinoma of the larynx (atypical carcinoid). Immunocytochemical demonstration of neuroendocrine markers (neuron-specific enolase and chromogranin-A) and presence of membrane-bound neurosecretory granules in the cells established the neuroendocrine nature of the tumour. In addition, the tumour was found to produce calcitonin, somatostatin and carcino-embryonic antigen (CEA). Calcitonin and somatostatin were also secreted. On the basis of this particular marker constellation the tumour closely resembles medullary thyroid carcinoma. Review of the recent literature on carcinoids of the larynx reveals immunoreactivity for calcitonin and CEA in a high percentage of cases.

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Year:  1990        PMID： 1970917     DOI： 10.1007/bf01600306

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  19 in total

1.  Oat-cell carcinoma of the larynx.

Authors:  M Kyriakos; B P Berlin; K DeSchryver-Kecskemeti
Journal:  Arch Otolaryngol       Date:  1978-03

2.  Prognostic factors in medullary thyroid carcinomas. Survival in relation to age, sex, stage, histology, immunocytochemistry, and DNA content.

Authors:  S Schröder; W Böcker; H Baisch; C G Bürk; H Arps; I Meiners; H Kastendieck; P U Heitz; G Klöppel
Journal:  Cancer       Date:  1988-02-15       Impact factor: 6.860

3.  Carcinoids: the prognostic effect of primary site histologic type variations.

Authors:  L A Johnson; P T Lavin; C G Moertel; L H Weiland; Y Y Dayal; W G Doos; S A Geller; H S Cooper; S R Masse; P F Engstrom
Journal:  J Surg Oncol       Date:  1986-10       Impact factor: 3.454

4.  Small cell anaplastic carcinoma of the larynx: review of the literature and report of a case.

Authors:  D P Vrabec; L J Bartels
Journal:  Laryngoscope       Date:  1980-10       Impact factor: 3.325

5.  The use of avidin-biotin interaction in immunoenzymatic techniques.

Authors:  J L Guesdon; T Ternynck; S Avrameas
Journal:  J Histochem Cytochem       Date:  1979-08       Impact factor: 2.479

Review 6.  Neuroendocrine carcinomas of the larynx. A study of two types, one of which mimics thyroid medullary carcinoma.

Authors:  J M Woodruff; A G Huvos; R A Erlandson; J P Shah; F P Gerold
Journal:  Am J Surg Pathol       Date:  1985-11       Impact factor: 6.394

Review 7.  Primary anaplastic small cell (oat cell) carcinoma of the larynx. Review of the literature and report of 18 cases.

Authors:  D R Gnepp; A Ferlito; V Hyams
Journal:  Cancer       Date:  1983-05-01       Impact factor: 6.860

Review 8.  Immunohistochemical evaluation of neuroendocrine cells and neoplasms of the lung.

Authors:  V E Gould; I Lee; W H Warren
Journal:  Pathol Res Pract       Date:  1988-04       Impact factor: 3.250

Review 9.  Carcinoid of the larynx: a report of three cases and a review of the literature.

Authors:  P H Blok; J J Manni; P van den Broek; U J van Haelst; J L Slooff
Journal:  Laryngoscope       Date:  1985-06       Impact factor: 3.325

10.  Medullary carcinoma of the thyroid presenting as tumours of the pharynx and larynx.

Authors:  E C Sweeney; L McDonnell; C O'Brien
Journal:  Histopathology       Date:  1981-05       Impact factor: 5.087
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  10 in total

1.  Metastatic neuroendocrine tumor of the esophagus with features of medullary thyroid carcinoma.

Authors:  Raymond M Fertig; Adam Alperstein; Carlos Diaz; Kyle D Klingbeil; Sameera S Vangara; Ryosuke Misawa; Jennifer Reed; Sudeep Gaudi
Journal:  Intractable Rare Dis Res       Date:  2017-08

2.  Can Medullary Thyroid Carcinoma Arise in Thyroglossal Duct Cysts? A Search for Parafollicular C-cells in 41 Resected Cases.

Authors:  Tracy Stein; Paari Murugan; Faqian Li; Mohamed I El Hag
Journal:  Head Neck Pathol       Date:  2017-05-23

Review 3.  [Thyroid C cells and their pathology: Part 1: normal C cells, - C cell hyperplasia, - precursor of familial medullary thyroid carcinoma].

Authors:  S Ting; S Synoracki; K W Schmid
Journal:  Pathologe       Date:  2015-05       Impact factor: 1.011

Review 4.  [Definition of R1 resection in thyroid carcinoma].

Authors:  S Synoracki; Ch Wittekind; H Dralle; K W Schmid
Journal:  Chirurg       Date:  2017-09       Impact factor: 0.955

Review 5.  [Thyroid C cells and their pathology: Part 2: Medullary thyroid carcinoma].

Authors:  S Synoracki; S T Schmid; S Ting; K W Schmid
Journal:  Pathologe       Date:  2015-05       Impact factor: 1.011

6.  Immunohistochemical and fine structural characterization of primary carcinoid tumors of the larynx.

Authors:  R Dieler; J Dämmrich
Journal:  Eur Arch Otorhinolaryngol       Date:  1995       Impact factor: 2.503

7.  Neuroendocrine neoplasms of the larynx. Importance of the correct diagnosis and differences between atypical carcinoid tumors and small-cell neuroendocrine carcinoma.

Authors:  F M Gripp; E K Risse; H Leverstein; G B Snow; C J Meijer
Journal:  Eur Arch Otorhinolaryngol       Date:  1995       Impact factor: 2.503

8.  Neuroendocrine Tumors of the Head and Neck: A Selected Review with Emphasis on Terminology.

Authors:  Stacey E. Mills
Journal:  Endocr Pathol       Date:  1996       Impact factor: 3.943

9.  Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid.

Authors:  Lauren LaBryer; Ravindranauth Sawh; Colby McLaurin; R Hal Scofield
Journal:  Case Rep Endocrinol       Date:  2015-09-28

Review 10.  Laryngeal Neuroendocrine Tumor With Elevated Serum Calcitonin: A Diagnostic and Therapeutic Challenge. Case Report and Review of Literature.

Authors:  Tiziana Feola; Giulia Puliani; Franz Sesti; Roberta Modica; Marco Biffoni; Cira Di Gioia; Raffaella Carletti; Emanuela Anastasi; Valentina Di Vito; Roberta Centello; Andrea Lenzi; Andrea M Isidori; Antongiulio Faggiano; Elisa Giannetta
Journal:  Front Endocrinol (Lausanne)       Date:  2020-07-16       Impact factor: 5.555
  10 in total

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