Literature DB >> 1970794

An alpha satellite DNA polymorphism specific for the centromeric region of chromosome 13.

A C Warren1, A M Bowcock, L A Farrer, S E Antonarakis.   

Abstract

Alpha satellite DNA is composed of variants of a short consensus sequence that are repeated in tandem arrays in the centromeric heterochromatin of each human chromosome. To define centromeric markers for linkage studies, we screened human genomic DNA for restriction fragment length polymorphisms using a probe detecting alphoid sequences on chromosomes 13 and 21. We describe one such DNA polymorphism. Analysis of linkage of this DNA marker to other polymorphic markers in the CEPH pedigrees demonstrates linkage to markers on the proximal long arm of chromosome 13 and defines the centromeric end of the linkage map of this chromosome.

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Year:  1990        PMID： 1970794     DOI： 10.1016/0888-7543(90)90525-y

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  4 in total

Review 1.  A survey of the genomic distribution of alpha satellite DNA on all the human chromosomes, and derivation of a new consensus sequence.

Authors:  K H Choo; B Vissel; A Nagy; E Earle; P Kalitsis
Journal:  Nucleic Acids Res       Date:  1991-03-25       Impact factor: 16.971

Review 2.  Precarious maintenance of simple DNA repeats in eukaryotes.

Authors:  Alexander J Neil; Jane C Kim; Sergei M Mirkin
Journal:  Bioessays       Date:  2017-07-13       Impact factor: 4.345

3.  Organization and evolution of an alpha satellite DNA subset shared by human chromosomes 13 and 21.

Authors:  G M Greig; P E Warburton; H F Willard
Journal:  J Mol Evol       Date:  1993-11       Impact factor: 2.395

4.  On the mode of evolution of alpha satellite DNA in human populations.

Authors:  B Marçais; J P Charlieu; B Allain; E Brun; M Bellis; G Roizès
Journal:  J Mol Evol       Date:  1991-07       Impact factor: 2.395
  4 in total

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