Literature DB >> 19706736

Dynamic balancing: DEPTOR tips the scales.

Christopher G Proud1.   

Abstract

The mammalian target of rapamycin, mTOR, is a key node in cellular regulation: its dysregulation is important in a number of disease states, including various cancers. A recent study identifies a new partner and regulator of mTOR, which can alter the balance of signaling downstream of mTOR and appears to be important in certain cancers, such as multiple myelomas.

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Year:  2009        PMID： 19706736     DOI： 10.1093/jmcb/mjp012

Source DB:  PubMed          Journal:  J Mol Cell Biol        ISSN： 1759-4685            Impact factor:   6.216


  19 in total

1.  DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

Authors:  Yongchao Zhao; Xiufang Xiong; Yi Sun
Journal:  Mol Cell       Date:  2011-10-21       Impact factor: 17.970

2.  DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells.

Authors:  Pooja Agrawal; Joseph Reynolds; Shereen Chew; Deepak A Lamba; Robert E Hughes
Journal:  J Biol Chem       Date:  2014-09-25       Impact factor: 5.157

3.  Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy.

Authors:  Abid A Kazi; Ly Hong-Brown; Susan M Lang; Charles H Lang
Journal:  Mol Med       Date:  2011-05-19       Impact factor: 6.354

4.  DEPTOR regulates vascular endothelial cell activation and proinflammatory and angiogenic responses.

Authors:  Sarah Bruneau; Hironao Nakayama; Craig B Woda; Evelyn A Flynn; David M Briscoe
Journal:  Blood       Date:  2013-07-23       Impact factor: 22.113

5.  Resveratrol inhibits mTOR signaling by targeting DEPTOR.

Authors:  Meilian Liu; Feng Liu
Journal:  Commun Integr Biol       Date:  2011-07-01

6.  DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia.

Authors:  Y Hu; H Su; C Liu; Z Wang; L Huang; Q Wang; S Liu; S Chen; J Zhou; P Li; Z Chen; H Liu; G Qing
Journal:  Oncogene       Date:  2016-09-05       Impact factor: 9.867

7.  Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR.

Authors:  Meilian Liu; Sarah Ann Wilk; Anping Wang; Lijun Zhou; Rui-Hong Wang; Wataru Ogawa; Chuxia Deng; Lily Q Dong; Feng Liu
Journal:  J Biol Chem       Date:  2010-09-17       Impact factor: 5.157

8.  microRNA-181a downregulates deptor for TGFβ-induced glomerular mesangial cell hypertrophy and matrix protein expression.

Authors:  Soumya Maity; Amit Bera; Nandini Ghosh-Choudhury; Falguni Das; Balakuntalam S Kasinath; Goutam Ghosh Choudhury
Journal:  Exp Cell Res       Date:  2018-02-01       Impact factor: 3.905

Review 9.  Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application.

Authors:  Yongchao Zhao; Yi Sun
Journal:  Neoplasia       Date:  2012-05       Impact factor: 5.715

10.  Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy.

Authors:  Falguni Das; Nandini Ghosh-Choudhury; Amit Bera; Nirmalya Dey; Hanna E Abboud; Balakuntalam S Kasinath; Goutam Ghosh Choudhury
Journal:  J Biol Chem       Date:  2013-01-28       Impact factor: 5.157
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