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Literature DB >> 19705434

Platelet-derived growth factor is involved in the differentiation of second heart field-derived cardiac structures in chicken embryos.

Noortje A M Bax¹, Heleen Lie-Venema, Rebecca Vicente-Steijn, Steven B Bleyl, Nynke M S Van Den Akker, Saskia Maas, Robert E Poelmann, Adriana C Gittenberger-de Groot.

Abstract

For the establishment of a fully functional septated heart, addition of myocardium from second heart field-derived structures is important. Platelet-derived growth factors (PDGFs) are known for their role in cardiovascular development. In this study, we aim to elucidate this role of PDGF-A, PDGF-C, and their receptor PDGFR-alpha. We analyzed the expression patterns of PDGF-A, -C, and their receptor PDGFR-alpha during avian heart development. A spatiotemporal pattern of ligands was seen with colocalization of the PDGFR-alpha. This was found in second heart field-derived myocardium as well as the proepicardial organ (PEO) and epicardium. Mechanical inhibition of epicardial outgrowth as well as chemical disturbance of PDGFR-alpha support a functional role of the ligands and the receptor in cardiac development.

Entities: Gene Species

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Year: 2009 PMID： 19705434 DOI： 10.1002/dvdy.22073

Source DB: PubMed Journal: Dev Dyn ISSN： 1058-8388 Impact factor: 3.780

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Cited

13 in total

1. Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling.

Authors: Christopher L Smith; Seung Tae Baek; Caroline Y Sung; Michelle D Tallquist
Journal: Circ Res Date: 2011-04-21 Impact factor: 17.367

Review 2. Cilia and coordination of signaling networks during heart development.

Authors: Karen Koefoed; Iben Rønn Veland; Lotte Bang Pedersen; Lars Allan Larsen; Søren Tvorup Christensen
Journal: Organogenesis Date: 2013-12-17 Impact factor: 2.500

3. Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field.

Authors: Noortje A M Bax; Steven B Bleyl; Radiosa Gallini; Lambertus J Wisse; Jennifer Hunter; Angelique A M Van Oorschot; Edris A F Mahtab; Heleen Lie-Venema; Marie-Jose Goumans; Christer Betsholtz; Adriana C Gittenberger-de Groot
Journal: Dev Dyn Date: 2010-08 Impact factor: 3.780

4. Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart.

Authors: James J H Chong; Hans Reinecke; Mineo Iwata; Beverly Torok-Storb; April Stempien-Otero; Charles E Murry
Journal: Stem Cells Dev Date: 2013-03-26 Impact factor: 3.272

Review 5. Developmental Pathways of Cardiac Fibroblasts.

Authors: Michelle D Tallquist
Journal: Cold Spring Harb Perspect Biol Date: 2020-04-01 Impact factor: 10.005

6. In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1.

Authors: Noortje A M Bax; Angelique A M van Oorschot; Saskia Maas; Jerry Braun; John van Tuyn; Antoine A F de Vries; Adriana C Gittenberger-de Groot; Marie-José Goumans
Journal: Basic Res Cardiol Date: 2011-04-24 Impact factor: 17.165

10. Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart.

Authors: Radiosa Gallini; Jenni Huusko; Seppo Ylä-Herttuala; Christer Betsholtz; Johanna Andrae
Journal: PLoS One Date: 2016-08-11 Impact factor: 3.240