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Literature DB >> 1970538

Chronic handling modifies the anxiolytic effect of diazepam in the elevated plus-maze.

Abstract

Rats treated for 3 days with diazepam demonstrated a clear anxiolytic action of the drug as assessed in the elevated plus-maze. However, in a chronic experiment, in which all rats were handled for 28 days, no anxiolytic effect of diazepam could be shown either in rats treated for 3 days or in those treated for 28 days. These results suggest that there is an interaction between handling and the anxiolytic effect of diazepam.

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Year: 1990 PMID： 1970538 DOI： 10.1016/0014-2999(90)94806-9

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

13 in total

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Journal: Experientia Date: 1991-10-15

2. Lithium administration to preadolescent rats causes long-lasting increases in anxiety-like behavior and has molecular consequences.

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4. Decreased anxiety levels related to aging.

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Journal: Exp Brain Res Date: 2005-04-26 Impact factor: 1.972

5. Changes in benzodiazepine-GABA receptor coupling in an accumbens-habenula circuit after chronic diazepam treatment.

Authors: R R Brett; J A Pratt
Journal: Br J Pharmacol Date: 1995-11 Impact factor: 8.739

6. Effects of diazepam on behavioural and antinociceptive responses to the elevated plus-maze in male mice depend upon treatment regimen and prior maze experience.

Authors: R J Rodgers; C Lee; J K Shepherd
Journal: Psychopharmacology (Berl) Date: 1992 Impact factor: 4.530

7. Ethological evaluation of the effects of acute and chronic buspirone treatment in the murine elevated plus-maze test: comparison with haloperidol.

Authors: J C Cole; R J Rodgers
Journal: Psychopharmacology (Berl) Date: 1994-03 Impact factor: 4.530