| Literature DB >> 19703392 |
Agnieszka Chacinska1, Carla M Koehler, Dusanka Milenkovic, Trevor Lithgow, Nikolaus Pfanner.
Abstract
Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial membranes. There is an amazingly versatile set of machineries and mechanisms, and at least four different pathways, for the importing and sorting of mitochondrial precursor proteins. The translocases that catalyze these processes are highly dynamic machines driven by the membrane potential, ATP, or redox reactions, and they cooperate with molecular chaperones and assembly complexes to direct mitochondrial proteins to their correct destinations. Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis.Entities:
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Year: 2009 PMID： 19703392 PMCID： PMC4099469 DOI： 10.1016/j.cell.2009.08.005
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582