BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). METHODS: Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance. RESULTS: Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03). CONCLUSIONS: These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.
BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). METHODS: Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance. RESULTS: Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03). CONCLUSIONS: These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.
Authors: S T Nadler; J P Stoehr; K L Schueler; G Tanimoto; B S Yandell; A D Attie Journal: Proc Natl Acad Sci U S A Date: 2000-10-10 Impact factor: 11.205
Authors: C Taghibiglou; A Carpentier; S C Van Iderstine; B Chen; D Rudy; A Aiton; G F Lewis; K Adeli Journal: J Biol Chem Date: 2000-03-24 Impact factor: 5.157
Authors: Laura A Cox; Anthony G Comuzzie; Lorena M Havill; Genesio M Karere; Kimberly D Spradling; Michael C Mahaney; Peter W Nathanielsz; Daniel P Nicolella; Robert E Shade; Saroja Voruganti; John L VandeBerg Journal: ILAR J Date: 2013
Authors: Paul B Higgins; Perla J Rodriguez; V Saroja Voruganti; Vicki Mattern; Raul A Bastarrachea; Karen Rice; Timothy Raabe; Anthony G Comuzzie Journal: Am J Phys Anthropol Date: 2013-11-06 Impact factor: 2.868
Authors: Subhash Kamath; Alberto O Chavez; Amalia Gastaldelli; Francesca Casiraghi; Glenn A Halff; Gregory A Abrahamian; Alberto M Davalli; Raul A Bastarrachea; Anthony G Comuzzie; Rodolfo Guardado-Mendoza; Lilia M Jimenez-Ceja; Vicki Mattern; Ana Maria Paez; Andrea Ricotti; Mary E Tejero; Paul B Higgins; Iram Pablo Rodriguez-Sanchez; Devjit Tripathy; Ralph A DeFronzo; Edward J Dick; Gary W Cline; Franco Folli Journal: PLoS One Date: 2011-11-18 Impact factor: 3.240