Literature DB >> 19702328

The glutamate switch is present in all seven clades of AAA+ protein.

Maria Elena Mogni1, Alessandro Costa, Charikleia Ioannou, Stephen D Bell.   

Abstract

Recent work has identified a "glutamate switch" in six of the seven clades of AAA+ ATPases. The glutamate switch acts to transduce information regarding substrate binding to the ATPase active site. We provide biochemical evidence that a highly conserved threonine residue acts as a glutamate switch in the replicative helicase, MCM, and, thus, reveal that the glutamate switch is a feature common to all seven AAA+ clades.

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Year:  2009        PMID： 19702328     DOI： 10.1021/bi9012512

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  5 in total

1.  The glutamate switch of bacteriophage T7 DNA helicase: role in coupling nucleotide triphosphate (NTP) and DNA binding to NTP hydrolysis.

Authors:  Ajit K Satapathy; Charles C Richardson
Journal:  J Biol Chem       Date:  2011-05-12       Impact factor: 5.157

2.  Insights into the mechanism and regulation of the CbbQO-type Rubisco activase, a MoxR AAA+ ATPase.

Authors:  Yi-Chin Candace Tsai; Fuzhou Ye; Lynette Liew; Di Liu; Shashi Bhushan; Yong-Gui Gao; Oliver Mueller-Cajar
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-17       Impact factor: 11.205

3.  Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation.

Authors:  Joshua Pajak; Rockney Atz; Brendan J Hilbert; Marc C Morais; Brian A Kelch; Paul J Jardine; Gaurav Arya
Journal:  Proc Natl Acad Sci U S A       Date:  2021-04-27       Impact factor: 11.205

4.  Molecular basis of nucleotide-dependent substrate engagement and remodeling by an AAA+ activator.

Authors:  Vidya C Darbari; Ed Lawton; Duo Lu; Patricia C Burrows; Simone Wiesler; Nicolas Joly; Nan Zhang; Xiaodong Zhang; Martin Buck
Journal:  Nucleic Acids Res       Date:  2014-07-25       Impact factor: 16.971

5.  Molecular dynamics of DNA translocation by FtsK.

Authors:  Joshua Pajak; Gaurav Arya
Journal:  Nucleic Acids Res       Date:  2022-08-10       Impact factor: 19.160
  5 in total

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