Debasis Samanta1, Robert B Kargbo, Gregory R Cook. 1. Department of Chemistry and Molecular Biology, North Dakota State University, Department 2735, P.O. Box 6050, Fargo, North Dakota 58108-6050, usa.
Abstract
The asymmetric intramolecular indium-mediated cyclization reaction delivers chromanes with excellent diastereoselectivity (68-91% yield, dr >99:1). The reaction was efficient for aryl substrates with both electron-withdrawing and -donating groups. Carboxylic acid additives were found to be necessary for optimal reaction.
The asymmetric intramolecular indium-mediated cyclization reaction delivers n class="Chemical">chromanes with excellent diastereoselectivity (68-91% yield, dr >99:1). The reaction was efficient for aryl substrates with both electron-withdrawing and -donating groups. Carboxylic acid additives were found to be necessary for optimal reaction.
Authors: G C Rovnyak; S Z Ahmed; C Z Ding; S Dzwonczyk; F N Ferrara; W G Humphreys; G J Grover; D Santafianos; K S Atwal; A J Baird; L G McLaughlin; D E Normandin; P G Sleph; S C Traeger Journal: J Med Chem Date: 1997-01-03 Impact factor: 7.446
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