Literature DB >> 19702169

Synthesis of 1,2,4-triazine derivatives as potential anti-anxiety and anti-inflammatory agents.

Pooja Mullick1, Suroor A Khan, Tauseef Begum, Surajpal Verma, Darpan Kaushik, Ozair Alam.   

Abstract

A series of 1,2,4-triazine derivatives Va (1-24) and Vb (1-24) were synthesized and evaluated for their anti-anxiety and anti-inflammatory activities. The structures of the synthesized compounds were confirmed on the basis of their spectral data. Many of the triazine compounds were found to possess good activity. Especially, compounds bearing the sulfur atom showed better activity than those bearing the oxygen atom.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19702169

Source DB:  PubMed          Journal:  Acta Pol Pharm        ISSN： 0001-6837            Impact factor:   0.330


  7 in total

Review 1.  Transition metal-free one-pot synthesis of nitrogen-containing heterocycles.

Authors:  Simpal Kumari; Dharma Kishore; Sarvesh Paliwal; Rajani Chauhan; Jaya Dwivedi; Aakanksha Mishra
Journal:  Mol Divers       Date:  2015-06-09       Impact factor: 2.943

2.  An efficient and facile synthesis of new tetracyclic fused pyrazolo[4,3-c][1,2,4]triazino[4,5-a]quinolin-4(5H)-ones.

Authors:  Mohsen A-M Gomaa; Huda A Ali
Journal:  Mol Divers       Date:  2018-07-03       Impact factor: 2.943

3.  Involvement of molecular chaperones and the transcription factor Nrf2 in neuroprotection mediated by para-substituted-4,5-diaryl-3-thiomethyl-1,2,4-triazines.

Authors:  Fariba Khodagholi; Niloufar Ansari; Mohsen Amini; Solaleh Khoramian Tusi
Journal:  Cell Stress Chaperones       Date:  2012-01-04       Impact factor: 3.667

4.  2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule.

Authors:  Kamila Buzun; Agnieszka Gornowicz; Roman Lesyk; Anna Kryshchyshyn-Dylevych; Andrzej Gzella; Robert Czarnomysy; Gniewomir Latacz; Agnieszka Olejarz-Maciej; Jadwiga Handzlik; Krzysztof Bielawski; Anna Bielawska
Journal:  Int J Mol Sci       Date:  2022-04-07       Impact factor: 6.208

5.  Synthesis and anticancer activity of some new s-glycosyl and s-alkyl 1,2,4-triazinone derivatives.

Authors:  Hosam A Saad; Ahmed H Moustafa
Journal:  Molecules       Date:  2011-07-04       Impact factor: 4.411

6.  The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon Cancer Cells.

Authors:  Agnieszka Gornowicz; Anna Szymanowska; Mariusz Mojzych; Krzysztof Bielawski; Anna Bielawska
Journal:  Int J Mol Sci       Date:  2020-07-23       Impact factor: 5.923

7.  An Optimized Synthesis, Molecular Structure and Characterization of Benzylic Derivatives of 1,2,4-Triazin-3,5(2H,4H)-dione.

Authors:  Long-Chih Hwang; Shiun-Yau Yang; Chung-Lin Chuang; Gene-Hsiang Lee
Journal:  Molecules       Date:  2017-11-08       Impact factor: 4.411
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.