BACKGROUND: Survival rates after curative surgery for gastric cancer are disappointing. Therefore adjuvant therapeutic strategies are required. AIM: To analyze survival and side effects of treatment among gastric cancer patients treated with adjuvant chemo radiotherapy after curative resection of gastric adenocarcinoma. MATERIAL AND METHODS: Retrospective review of medical records of 74 patients aged 20 to 74 years, treated with complete resection of gastric adenocarcinoma followed by adjuvant chemo radiation. Survival analysis was based on the records and information from the National Mortality Registry. RESULTS: Five years survival fluctuated from 50% among patients in stage IB to 25% among those is stage IV. Significant acute toxicity was observed in 23 patients (31%). No patients died due to acute toxicity. Eleven patients (16.4%) developed significant late toxicity, with two possible deaths related to treatment. CONCLUSIONS: Postoperative chemo radiotherapy is feasible in our experience. Continues infusion of 5-fluoruracil is recommended to reduce toxicity.
BACKGROUND: Survival rates after curative surgery for gastric cancer are disappointing. Therefore adjuvant therapeutic strategies are required. AIM: To analyze survival and side effects of treatment among gastric cancerpatients treated with adjuvant chemo radiotherapy after curative resection of gastric adenocarcinoma. MATERIAL AND METHODS: Retrospective review of medical records of 74 patients aged 20 to 74 years, treated with complete resection of gastric adenocarcinoma followed by adjuvant chemo radiation. Survival analysis was based on the records and information from the National Mortality Registry. RESULTS: Five years survival fluctuated from 50% among patients in stage IB to 25% among those is stage IV. Significant acute toxicity was observed in 23 patients (31%). No patients died due to acute toxicity. Eleven patients (16.4%) developed significant late toxicity, with two possible deaths related to treatment. CONCLUSIONS: Postoperative chemo radiotherapy is feasible in our experience. Continues infusion of 5-fluoruracil is recommended to reduce toxicity.
Authors: Bettina Müller; Carlos García; José A Sola; Wanda Fernandez; Patrick Werner; Mauricio Cerda; Jeannie Slater; Carlos Benavides; Jorge Arancibia; Rodrigo Ascui; Felipe Reyes; Mary Ann Stevens; Juan Pablo Miranda; Martin Buchholtz; Alejandro H Corvalan Journal: Ecancermedicalscience Date: 2021-06-07