Literature DB >> 1970155

Similar early gene responses to ligand-activated EGFR and neu tyrosine kinases in NIH3T3 cells.

P Koskinen1, H Lehväslaiho, H MacDonald-Bravo, K Alitalo, R Bravo.   

Abstract

We have compared the responses of serum-inducible immediate early genes to ligand activation of the epidermal growth factor receptor (EGFR) or a hybrid EGFR/neu receptor containing the intracellular domain of the neu proto-oncogene. Few differences in mRNA induction kinetics were found, emphasizing the functional similarity of these structurally related tyrosine kinases.

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Year:  1990        PMID: 1970155

Source DB:  PubMed          Journal:  Oncogene        ISSN: 0950-9232            Impact factor:   9.867


  3 in total

1.  Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase.

Authors:  L Lehtola; M Nistér; E Hölttä; B Westermark; K Alitalo
Journal:  Cell Regul       Date:  1991-08

2.  Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling.

Authors:  D Graus-Porta; R R Beerli; N E Hynes
Journal:  Mol Cell Biol       Date:  1995-03       Impact factor: 4.272

3.  A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.

Authors:  S Lev; D Givol; Y Yarden
Journal:  EMBO J       Date:  1991-03       Impact factor: 11.598

  3 in total

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