| Literature DB >> 1970124 |
R A Byrn1, J Mordenti, C Lucas, D Smith, S A Marsters, J S Johnson, P Cossum, S M Chamow, F M Wurm, T Gregory, J E Groopman, D J Capon.
Abstract
Molecular fusions of CD4, the receptor for human immunodeficiency virus (HIV), with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of recombinant soluble CD4, and certain properties of IgG, notably long plasma half-life and Fc receptor binding. Here we show that a CD4 immunoadhesin can mediate antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells, although, unlike natural anti-gp120 antibodies, it does not allow ADCC towards uninfected CD4-expressing cells that have bound soluble gp120 to the CD4 on their surface. In addition, CD4 immunoadhesin, like natural IgG molecules, is efficiently transferred across the placenta of a primate. These observations have implications for the therapeutic application of CD4 immunoadhesins, particularly in the area of perinatal transmission of HIV infection.Entities:
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Year: 1990 PMID： 1970124 DOI： 10.1038/344667a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962