Literature DB >> 19700316

Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses.

Kristjan S Gudmundsson1, Brian A Johns, Jason Weatherhead.   

Abstract

Synthesis of several pyrazolo[1,5-c]pyrimidines, pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described.

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Year:  2009        PMID： 19700316     DOI： 10.1016/j.bmcl.2009.08.009

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators.

Authors:  Brad M Savall; Dongpei Wu; Devin M Swanson; Mark Seierstad; Nyantsz Wu; Jorge Vives Martinez; Beatriz García Olmos; Brian Lord; Kevin Coe; Tatiana Koudriakova; Timothy W Lovenberg; Nicholas I Carruthers; Michael P Maher; Michael K Ameriks
Journal:  ACS Med Chem Lett       Date:  2018-12-26       Impact factor: 4.345

2.  Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines.

Authors:  Alice Mr Bernardino; Alexandre R Azevedo; Luiz Cs Pinheiro; Júlio C Borges; Izabel Cp Paixão; Milene Mesquita; Thiago Ml Souza; Maurício S Dos Santos
Journal:  Org Med Chem Lett       Date:  2012-02-01

3.  18F-labeled pyrazolo[1,5-a]pyrimidine derivatives: synthesis from 2,4-dinitrobenzamide and tosylate precursors and comparative biological evaluation for tumor imaging with positron emission tomography.

Authors:  Jingli Xu; Hang Liu; Guixia Li; Yong He; Rui Ding; Xiao Wang; Man Feng; Shuting Zhang; Yurong Chen; Shilei Li; Mingxia Zhao; Yingruo Li; Chuanmin Qi; Yonghong Dang
Journal:  Molecules       Date:  2012-03-27       Impact factor: 4.411

4.  Crystal structure determination, Hirshfeld surface, crystal void, inter-molecular inter-action energy analyses, as well as DFT and energy framework calculations of 2-(4-oxo-4,5-di-hydro-1H-pyra-zolo[3,4-d]pyrimidin-1-yl)acetic acid.

Authors:  Ezaddine Irrou; Younesse Ait Elmachkouri; Ali Oubella; Hassan Ouchtak; Samira Dalbouha; Joel T Mague; Tuncer Hökelek; Lhoussaine El Ghayati; Nada Kheira Sebbar; Mohamed Labd Taha
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2022-08-31
  4 in total

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