| Literature DB >> 19700240 |
Kin Tak Chan1, Kwan Li, Shiu Lam Liu, Kee Hung Chu, Melvin Toh, Wei Dong Xie.
Abstract
Cucurbitacin B is a natural anti-cancer compound found in Cucurbitaceae. Although the anti-cancer activity of cucurbitacin B in human leukemia cells has been reported, the underlining mechanism is still unclear. To clarify its anti-cancer activity and the mechanism of action, five different leukemia cell lines (CCRF-CEM, K562, MOLT-4, RPMI-8226 and SR) of the National Cancer Institute panel were treated with cucurbitacin B. Leukemia cell growth was inhibited by cucurbitacin B with GI(50) ranged from 15.6 nM to 35.3 nM and the growth inhibition effect was attributable to G2/M phase arrest and apoptosis. Western blotting analysis of cell signaling molecules indicated that cucurbitacin B inhibits STAT3 activation and the Raf/MEK/ERK pathway in the K562 cells. Crown Copyright 2009. Published by Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19700240 DOI： 10.1016/j.canlet.2009.07.015
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679