BACKGROUND: Although left ventricular (LV) and left atrial (LA) echo indices may reliably reflect loading conditions in patients with hypertrophic cardiomyopathy (HCM), little is known about 2-dimensional strain imaging. We evaluated LV and LA 2-dimensional strain imaging in relation to long-term outcome in patients with HCM. METHODS: Fifty consecutive patients (58% men, aged 51 +/- 18 years) with familial HCM and normal LV ejection fraction underwent 2-dimensional LV and LA strain imaging; total LA strain was defined as the sum of maximum positive and maximum negative atrial strain. Patients were followed up for 12 months for cardiovascular events, defined as death or hospitalization for cardiovascular causes. RESULTS: Twenty patients (40%) experienced an event after a median time of 98 days: 2 (4%) died and 18 (36%) were hospitalized. In multivariate analysis, total LA strain was the strongest predictor of 12-month outcome (odds ratio 0.858, 95% CI 0.771-0.954, P = .005); a cutoff of 21% predicted events with 90% sensitivity and 86% specificity. Total LA strain was also an independent predictor of atrial fibrillation requiring hospitalization (odds ratio 0.853, 95% CI 0.748-0.972, P = .017). CONCLUSIONS: In patients with HCM and normal systolic function, total LA strain predicts 12-month outcome in terms of death and/or hospitalization.
BACKGROUND: Although left ventricular (LV) and left atrial (LA) echo indices may reliably reflect loading conditions in patients with hypertrophic cardiomyopathy (HCM), little is known about 2-dimensional strain imaging. We evaluated LV and LA 2-dimensional strain imaging in relation to long-term outcome in patients with HCM. METHODS: Fifty consecutive patients (58% men, aged 51 +/- 18 years) with familial HCM and normal LV ejection fraction underwent 2-dimensional LV and LA strain imaging; total LA strain was defined as the sum of maximum positive and maximum negative atrial strain. Patients were followed up for 12 months for cardiovascular events, defined as death or hospitalization for cardiovascular causes. RESULTS: Twenty patients (40%) experienced an event after a median time of 98 days: 2 (4%) died and 18 (36%) were hospitalized. In multivariate analysis, total LA strain was the strongest predictor of 12-month outcome (odds ratio 0.858, 95% CI 0.771-0.954, P = .005); a cutoff of 21% predicted events with 90% sensitivity and 86% specificity. Total LA strain was also an independent predictor of atrial fibrillation requiring hospitalization (odds ratio 0.853, 95% CI 0.748-0.972, P = .017). CONCLUSIONS: In patients with HCM and normal systolic function, total LA strain predicts 12-month outcome in terms of death and/or hospitalization.
Authors: Mohamed F A Aly; Wessel P Brouwer; Sebastiaan A Kleijn; Albert C van Rossum; Otto Kamp Journal: Int J Cardiovasc Imaging Date: 2014-01-30 Impact factor: 2.357
Authors: Gregory R Hartlage; Jonathan H Kim; Patrick T Strickland; Alan C Cheng; Nima Ghasemzadeh; Maria A Pernetz; Stephen D Clements; B Robinson Williams Journal: Int J Cardiovasc Imaging Date: 2015-01-14 Impact factor: 2.357
Authors: Francesco Bandera; Anita Mollo; Matteo Frigelli; Giulia Guglielmi; Nicoletta Ventrella; Maria Concetta Pastore; Matteo Cameli; Marco Guazzi Journal: Front Cardiovasc Med Date: 2022-01-13
Authors: Christopher M Kramer; John P DiMarco; Paul Kolm; Carolyn Y Ho; Milind Y Desai; Raymond Y Kwong; Sarahfaye F Dolman; Patrice Desvigne-Nickens; Nancy Geller; Dong-Yun Kim; Martin S Maron; Evan Appelbaum; Michael Jerosch-Herold; Matthias G Friedrich; Jeanette Schulz-Menger; Stefan K Piechnik; Masliza Mahmod; Daniel Jacoby; James White; Amedeo Chiribiri; Adam Helms; Lubna Choudhury; Michelle Michels; William Bradlow; Michael Salerno; Dana K Dawson; Jonathan W Weinsaft; Colin Berry; Sherif F Nagueh; Chiara Buccarelli-Ducci; Anjali Owens; Barbara Casadei; Hugh Watkins; William S Weintraub; Stefan Neubauer Journal: JACC Clin Electrophysiol Date: 2021-06-30