| Literature DB >> 19698730 |
M Iqbal Choudhary1, Mohammad Yasin Mohammad, Syed Ghulam Musharraf, Masood Parvez, Amal Al-Aboudi.
Abstract
Structural transformation of the steroidal lactone, oxandrolone (1), by suspended-cell cultures of the plant pathogen fungus Rhizopus stolonifer, resulted in the production of three new metabolites. These metabolites were identified as 11alpha-hydroxyoxandrolone (2), 6alpha-hydroxyoxandrolone (3) and 9alpha-hydroxyoxandrolone (4), by different spectroscopic methods and single-crystal X-ray diffraction analysis for metabolite 2. Compounds 1 and 3 showed a significant beta-glucuronidase inhibitory activity.Entities:
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Year: 2009 PMID： 19698730 DOI： 10.1016/j.steroids.2009.08.003
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668