Literature DB >> 19697926

ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity.

Li-Mei Li1, Guo-You Li, Jian-Xin Pu, Wei-Lie Xiao, Li-Sheng Ding, Han-Dong Sun.   

Abstract

Nine new ent-kauranoids, sculponins D-L (1-9), and 14 known diterpenoids (10-23) were isolated from the aerial parts of Isodon sculponeatus. The structures of the new diterpenoids were determined by detailed interpretation of their 1D and 2D NMR spectra and HRESIMS. The isolated compounds were evaluated for their cytotoxic activities against a small panel of human cancer cell lines.

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Year:  2009        PMID： 19697926     DOI： 10.1021/np900406c

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

Review 1.  Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents.

Authors:  Takahiro Matsumoto; Tetsushi Watanabe
Journal:  Genes Environ       Date:  2020-04-16

Review 2.  Discovery and development of natural product oridonin-inspired anticancer agents.

Authors:  Ye Ding; Chunyong Ding; Na Ye; Zhiqing Liu; Eric A Wold; Haiying Chen; Christopher Wild; Qiang Shen; Jia Zhou
Journal:  Eur J Med Chem       Date:  2016-06-13       Impact factor: 6.514

3.  Flaccidoxide-13-Acetate Extracted from the Soft Coral Cladiella kashmani Reduces Human Bladder Cancer Cell Migration and Invasion through Reducing Activation of the FAK/PI3K/AKT/mTOR Signaling Pathway.

Authors:  Choo-Aun Neoh; Wen-Tung Wu; Guo-Fong Dai; Jui-Hsin Su; Chih-I Liu; Tzu-Rong Su; Yu-Jen Wu
Journal:  Molecules       Date:  2017-12-27       Impact factor: 4.411

Review 4.  Bioactive Natural Spirolactone-Type 6,7-seco-ent-Kaurane Diterpenoids and Synthetic Derivatives.

Authors:  Haonan Li; Runwei Jiao; Jiahui Mu; Shengtao Xu; Xu Li; Xianhua Wang; Zhanlin Li; Jinyi Xu; Huiming Hua; Dahong Li
Journal:  Molecules       Date:  2018-11-08       Impact factor: 4.411

5.  Promiscuous terpene synthases from Prunella vulgaris highlight the importance of substrate and compartment switching in terpene synthase evolution.

Authors:  Sean R Johnson; Wajid Waheed Bhat; Radin Sadre; Garret P Miller; Alekzander Sky Garcia; Björn Hamberger
Journal:  New Phytol       Date:  2019-04-08       Impact factor: 10.151

6.  A database-driven approach identifies additional diterpene synthase activities in the mint family (Lamiaceae).

Authors:  Sean R Johnson; Wajid Waheed Bhat; Jacob Bibik; Aiko Turmo; Britta Hamberger; Björn Hamberger
Journal:  J Biol Chem       Date:  2018-11-29       Impact factor: 5.157

Review 7.  Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents.

Authors:  Takahiro Matsumoto; Tetsushi Watanabe
Journal:  Genes Environ       Date:  2020-04-16

8.  Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis.

Authors:  Li-Chung Hu; Jui-Hsin Su; Michael Yen-Nan Chiang; Mei-Chin Lu; Tsong-Long Hwang; Yung-Husan Chen; Wan-Ping Hu; Nai-Cheng Lin; Wei-Hsien Wang; Lee-Shing Fang; Yueh-Hsiung Kuo; Ping-Jyun Sung
Journal:  Mar Drugs       Date:  2013-06-10       Impact factor: 5.118

Review 9.  Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound.

Authors:  Dahong Li; Tong Han; Jie Liao; Xu Hu; Shengtao Xu; Kangtao Tian; Xiaoke Gu; Keguang Cheng; Zhanlin Li; Huiming Hua; Jinyi Xu
Journal:  Int J Mol Sci       Date:  2016-08-24       Impact factor: 5.923
  9 in total

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