Literature DB >> 196977

[Resistance of a line of Djungarian hamster cells to 6-mercaptopurine].

E S Kakpakova, Iu S Massino, E V Moiseenko.   

Abstract

A cell line resistant to 6-mercaptopurine (6-MP) is isolated from Djungarian hamster embryonic fibroblasts transformed with SV-40, 6-MP resistance is due to the absence or complete inhibition of GGPRT activity. Initial and resistant cell cultures are similar in the growth rate and in the inoculation efficiency. Caryological analysis (differential chromosome staining--S-bands) revealed considerable caryotype rearrangements in both resistant and sensitive lines as compared with Djungarian hamster normal chromosome set, and also the appearance of specific chromosome markers.

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Year:  1976        PMID： 196977

Source DB:  PubMed          Journal:  Genetika        ISSN： 0016-6758


  3 in total

1.  Multinucleation-induced improvement of the spreading of transformed cells on the substratum.

Authors:  L A Lyass; A D Bershadsky; V I Gelfand; A S Serpinskaya; A A Stavrovskaya; J M Vasiliev; I M Gelfand
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

2.  Gene amplification in Djungarian hamster cell lines possessing decreased plasma membrane permeability for colchicine and some other drugs.

Authors:  A V Gudkov; J S Massino; O B Chernova; B P Kopnin
Journal:  Chromosoma       Date:  1985       Impact factor: 4.316

3.  The carcinogen benzo(e)pyrene is metabolized by DM15 cells without an uncoupling effect on their gap junctions.

Authors:  I V Budunova; L A Mittleman; R D Safaev; G A Belitsky
Journal:  Cell Biol Toxicol       Date:  1993 Apr-Jun       Impact factor: 6.691
  3 in total

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