Literature DB >> 19696218

Immunosuppressive drugs and Tregs: a critical evaluation!

Sacha A De Serres1, Mohamed H Sayegh, Nader Najafian.   

Abstract

To define therapeutic strategies that promote tolerance, it is of critical importance to determine the effects of immunosuppressive drugs on regulatory T cells (Tregs). This review discusses the current knowledge about the physiology of Tregs in humans, the role or Tregs in transplantation, and the impact of the different types of immunosuppressive agents on the frequency and functionality of Tregs in in vitro and in vivo systems.

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Year:  2009        PMID： 19696218     DOI： 10.2215/CJN.03180509

Source DB:  PubMed          Journal:  Clin J Am Soc Nephrol        ISSN： 1555-9041            Impact factor:   8.237


  29 in total

1.  Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype.

Authors:  K M Dwyer; D Hanidziar; P Putheti; P A Hill; S Pommey; J L McRae; A Winterhalter; G Doherty; S Deaglio; M Koulmanda; W Gao; S C Robson; T B Strom
Journal:  Am J Transplant       Date:  2010-11       Impact factor: 8.086

Review 2.  Immunology of idiopathic nephrotic syndrome.

Authors:  Manuela Colucci; Giorgia Corpetti; Francesco Emma; Marina Vivarelli
Journal:  Pediatr Nephrol       Date:  2017-04-27       Impact factor: 3.714

3.  Adoptive Cell Therapy with Tregs to Improve Transplant Outcomes: The Promise and the Stumbling Blocks.

Authors:  Mohamed B Ezzelarab; Angus W Thomson
Journal:  Curr Transplant Rep       Date:  2016-10-25

4.  Use of the ImmuKnow assay to evaluate the effect of alemtuzumab-depleting induction therapy on cell-mediated immune function after renal transplantation.

Authors:  Hao Zhou; Jian Lin; Shushang Chen; Liqiang Ma; Zhenzhen Qiu; Weidong Chen; Xin'an Zhang; Yi Zhang; Xiuquan Lin
Journal:  Clin Exp Nephrol       Date:  2012-10-06       Impact factor: 2.801

5.  Evaluation of alloreactivity in kidney transplant recipients treated with antithymocyte globulin versus IL-2 receptor blocker.

Authors:  L Cherkassky; M Lanning; P N Lalli; J Czerr; H Siegel; L Danziger-Isakov; T Srinivas; A Valujskikh; D A Shoskes; W Baldwin; R L Fairchild; E D Poggio
Journal:  Am J Transplant       Date:  2011-05-12       Impact factor: 8.086

6.  Effects of ginsenosides on regulatory T cell differentiation.

Authors:  Jisu Kim; Hyeyoung Byeon; Kyungtaek Im; Hyeyoung Min
Journal:  Food Sci Biotechnol       Date:  2017-11-23       Impact factor: 2.391

7.  Immune profile of pediatric renal transplant recipients following alemtuzumab induction.

Authors:  Sacha A De Serres; Bechara G Mfarrej; Ciara N Magee; Fanny Benitez; Isa Ashoor; Mohamed H Sayegh; William E Harmon; Nader Najafian
Journal:  J Am Soc Nephrol       Date:  2011-11-03       Impact factor: 10.121

8.  Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses.

Authors:  Masaaki Zaitsu; Fadi Issa; Joanna Hester; Bernard Vanhove; Kathryn J Wood
Journal:  JCI Insight       Date:  2017-10-05

9.  Ex vivo expansion of human Tregs by rabbit ATG is dependent on intact STAT3-signaling in CD4⁺ T cells and requires the presence of monocytes.

Authors:  O Boenisch; M Lopez; W Elyaman; C N Magee; U Ahmad; N Najafian
Journal:  Am J Transplant       Date:  2012-03-05       Impact factor: 8.086

10.  Lymphocyte phenotype during therapy for acute graft-versus-host disease: a brief report from BMT-CTN 0302.

Authors:  Javier Bolaños-Meade; Juan Wu; Brent R Logan; John E Levine; Vincent T Ho; Amin M Alousi; Daniel J Weisdorf; Leo Luznik
Journal:  Biol Blood Marrow Transplant       Date:  2012-12-12       Impact factor: 5.742
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