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Literature DB >> 19695480

Cosmeceuticals and silibinin.

Abstract

Cosmeceuticals are used for nourishing and improving the appearance of the skin and are also documented as effective agents for treating various dermatologic conditions. Cosmeceutical preparations from herbal origin are most popular among consumers because these agents are mostly nontoxic and possess strong antioxidant activity. Because oxidative stress is one of the major mechanisms for skin aging and dermatologic conditions, phytochemicals with proven antioxidant activity, such as silibinin, could be useful for treating many dermatologic conditions as well as skin aging. Silibinin is a flavonolignan compound from Silybum marianum (milk thistle plant) that possesses strong antioxidant activity and also modulates many molecular changes caused by xenobiotics and ultraviolet radiation to protect the skin. This contribution reviews the evidence generated from laboratory studies to support the scientific rationale for the effective use of silibinin in cosmeceutical preparations.

Entities: CellLine Chemical Disease Gene Species

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Year: 2009 PMID： 19695480 PMCID： PMC2767273 DOI： 10.1016/j.clindermatol.2009.05.012

Source DB: PubMed Journal: Clin Dermatol ISSN： 0738-081X Impact factor: 3.541

47 in total

1. Thymidine dinucleotides inhibit contact hypersensitivity and activate the gene for tumor necrosis factor alpha1.

Authors: P D Cruz; M Leverkus; I Dougherty; M J Gleason; M Eller; M Yaar; B A Gilchrest
Journal: J Invest Dermatol Date: 2000-02 Impact factor: 8.551

Review 2. Cosmeceuticals.

Authors: Christine M Choi; Diane S Berson
Journal: Semin Cutan Med Surg Date: 2006-09

Review 3. UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer.

Authors: F R de Gruijl; H J van Kranen; L H Mullenders
Journal: J Photochem Photobiol B Date: 2001-10 Impact factor: 6.252

4. Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels.

Authors: Rana P Singh; Sivanandhan Dhanalakshmi; Anil K Tyagi; Daniel C F Chan; Chapla Agarwal; Rajesh Agarwal
Journal: Cancer Res Date: 2002-06-01 Impact factor: 12.701

5. Effect of silibinin on the growth and progression of primary lung tumors in mice.

Authors: Rana P Singh; Gagan Deep; Manesh Chittezhath; Manjinder Kaur; Lori D Dwyer-Nield; Alvin M Malkinson; Rajesh Agarwal
Journal: J Natl Cancer Inst Date: 2006-06-21 Impact factor: 13.506

Review 6. Silymarin: a review of its clinical properties in the management of hepatic disorders.

Authors: K Wellington; B Jarvis
Journal: BioDrugs Date: 2001 Impact factor: 5.807

7. Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion.

Authors: J Zhao; Y Sharma; R Agarwal
Journal: Mol Carcinog Date: 1999-12 Impact factor: 4.784

8. Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin.

Authors: J Zhao; M Lahiri-Chatterjee; Y Sharma; R Agarwal
Journal: Carcinogenesis Date: 2000-04 Impact factor: 4.944

Review 9. Flavonoid antioxidant silymarin and skin cancer.

Authors: Rana P Singh; Rajesh Agarwal
Journal: Antioxid Redox Signal Date: 2002-08 Impact factor: 8.401

10. An assessment of the malignant potential of actinic keratoses and Bowen's disease: p53 and PCNA expression pattern correlate with the number of desmosomes.

Authors: Saeef Taher Ramzi; Motoyoshi Maruno; Noor Mohammad Khaskhely; Mohammed Abul Kasem Khan; Atsushi Takamiyagi; Hiroshi Uezato; Shigeo Nonaka
Journal: J Dermatol Date: 2002-09 Impact factor: 4.005

14 in total

Review 1. Cosmeceuticals: the new medicine of beauty.

Authors: Katherine I Martin; Dee Anna Glaser
Journal: Mo Med Date: 2011 Jan-Feb

Review 2. Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure.

Authors: Neera Tewari-Singh; Rajesh Agarwal
Journal: Ann N Y Acad Sci Date: 2016-06-21 Impact factor: 5.691

3. An Overview of Ultraviolet B Radiation-Induced Skin Cancer Chemoprevention by Silibinin.

Authors: Rahul Kumar; Gagan Deep; Rajesh Agarwal
Journal: Curr Pharmacol Rep Date: 2015-06-01

4. Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries.

Authors: Neera Tewari-Singh; Anil K Jain; Swetha Inturi; David A Ammar; Chapla Agarwal; Puneet Tyagi; Uday B Kompella; Robert W Enzenauer; J Mark Petrash; Rajesh Agarwal
Journal: Toxicol Appl Pharmacol Date: 2012-07-24 Impact factor: 4.219

Review 5. Phyto-pharmacological perspective of Silymarin: A potential prophylactic or therapeutic agent for COVID-19, based on its promising immunomodulatory, anti-coagulant and anti-viral property.

Authors: Partha Palit; Aparna Mukhopadhyay; Debprasad Chattopadhyay
Journal: Phytother Res Date: 2021-04-04 Impact factor: 6.388

6. Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation.

Authors: Neera Tewari-Singh; Anil K Jain; Swetha Inturi; Chapla Agarwal; Carl W White; Rajesh Agarwal
Journal: PLoS One Date: 2012-09-27 Impact factor: 3.240

7. Gene Expression Analysis and Metabolite Profiling of Silymarin Biosynthesis during Milk Thistle (Silybum marianum (L.) Gaertn.) Fruit Ripening.

Authors: Samantha Drouet; Duangjai Tungmunnithum; Éric Lainé; Christophe Hano
Journal: Int J Mol Sci Date: 2020-07-02 Impact factor: 5.923