Literature DB >> 19695380

Looking back in 2009 at the dawning of antiviral therapy now 50 years ago an historical perspective.

Erik De Clercq1.   

Abstract

In 1959, 5-iodo-2'-deoxyuridine (IDU) was described, the first antiviral drug ever to be (and still) marketed (for the topical treatment of herpetic keratitis). Now 50 years following the description (of the synthesis) of IDU, we have 50 compounds on the market that have been licensed for clinical use in the treatment of virus infections. Of those 50, exactly 25 have been formally approved as anti-HIV drugs; the other 25 have been formally approved for the treatment of other virus infections: herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), hepatitis B virus (HBV), hepatitis C virus (HCV), and influenza virus infections.

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Year:  2009        PMID： 19695380     DOI： 10.1016/S0065-3527(09)73001-5

Source DB:  PubMed          Journal:  Adv Virus Res        ISSN： 0065-3527            Impact factor:   9.937


  9 in total

1.  EASY-HIT: HIV full-replication technology for broad discovery of multiple classes of HIV inhibitors.

Authors:  Stephan Kremb; Markus Helfer; Werner Heller; Dieter Hoffmann; Horst Wolff; Andrea Kleinschmidt; Sabine Cepok; Bernhard Hemmer; Jörg Durner; Ruth Brack-Werner
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

2.  The Activity of Plant-Derived Ren's Oligopeptides-1 against the Pseudorabies Virus.

Authors:  Danmei Xiao; Yu He; Qin Xiao; Luxia Cai; Haoqi Wang; Aikebaier Reheman; Ke Xiao
Journal:  Animals (Basel)       Date:  2022-05-25       Impact factor: 3.231

3.  New trends in nucleoside biotechnology.

Authors:  I A Mikhailopulo; A I Miroshnikov
Journal:  Acta Naturae       Date:  2010-07       Impact factor: 1.845

4.  Historical perspectives in the development of antiviral agents against poxviruses.

Authors:  Erik De Clercq
Journal:  Viruses       Date:  2010-06-14       Impact factor: 5.818

5.  New 5-modified pyrimidine nucleoside inhibitors of mycobacterial growth.

Authors:  L A Alexandrova; E R Shmalenyuk; S N Kochetkov; V V Erokhin; T G Smirnova; S N Andreevskaia; L N Chernousova
Journal:  Acta Naturae       Date:  2010-04       Impact factor: 1.845

6.  Mangiferin, an anti-HIV-1 agent targeting protease and effective against resistant strains.

Authors:  Rui-Rui Wang; Yue-Dong Gao; Chun-Hui Ma; Xing-Jie Zhang; Cheng-Gang Huang; Jing-Fei Huang; Yong-Tang Zheng
Journal:  Molecules       Date:  2011-05-24       Impact factor: 4.411

Review 7.  Antiviral Activity of Ribosome-Inactivating Proteins.

Authors:  Lucía Citores; Rosario Iglesias; José M Ferreras
Journal:  Toxins (Basel)       Date:  2021-01-22       Impact factor: 4.546

Review 8.  Polysaccharides and Their Derivatives as Potential Antiviral Molecules.

Authors:  Hadrien Claus-Desbonnet; Elsa Nikly; Vanya Nalbantova; Diana Karcheva-Bahchevanska; Stanislava Ivanova; Guillaume Pierre; Niko Benbassat; Plamen Katsarov; Philippe Michaud; Paolina Lukova; Cédric Delattre
Journal:  Viruses       Date:  2022-02-18       Impact factor: 5.048

9.  Fighting viruses with antibiotics: an overlooked path.

Authors:  Philippe Colson; Didier Raoult
Journal:  Int J Antimicrob Agents       Date:  2016-08-05       Impact factor: 5.283
  9 in total

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