AIM: Osteopontin is a secreted, integrin-binding glycophosphoprotein that is overexpressed in many types of cancers and appears to be involved in carcinogenesis and cancer progression. To understand the role of osteopontin in carcinogenesis of cervical cancer, this study was designed to determine whether osteopontin is expressed in cervical cancer and carcinoma in situ (CIS) tissue as well as in normal cervical tissue. METHODS: The expression of osteopontin was immunohistochemically analysed from 68 normal cervix, 55 CIS and 52 invasive cervical cancer tissues using a paraffin-embedded tissue array. Immunostaining was evaluated by intensity and the percentage of stained cells. RESULTS: Osteopontin expression in normal, CIS and cervical cancer tissues was two of 68 (2.9%), 43 of 55 (78.2%) and 46 of 52 (88.4%), respectively (P < 0.01). High intensity (strong positive)/high proportion (more than 50%) staining seen in CIS and cervical cancer tissue samples was 45 of 55 (81.8%)/22 of 55 (40.0%) and 50 of 52 (96.2%)/31 of 52 (59.7%), respectively (P = 0.029 and P = 0.054). There was no significant correlation between the immunostaining score and stage and the immunostaining score and survival. CONCLUSION: Osteopontin may have a potential use as a diagnostic factor for cervical cancer and osteopontin expression is closely correlated with carcinogenesis and invasion of cervical cancer.
AIM: Osteopontin is a secreted, integrin-binding glycophosphoprotein that is overexpressed in many types of cancers and appears to be involved in carcinogenesis and cancer progression. To understand the role of osteopontin in carcinogenesis of cervical cancer, this study was designed to determine whether osteopontin is expressed in cervical cancer and carcinoma in situ (CIS) tissue as well as in normal cervical tissue. METHODS: The expression of osteopontin was immunohistochemically analysed from 68 normal cervix, 55 CIS and 52 invasive cervical cancer tissues using a paraffin-embedded tissue array. Immunostaining was evaluated by intensity and the percentage of stained cells. RESULTS:Osteopontin expression in normal, CIS and cervical cancer tissues was two of 68 (2.9%), 43 of 55 (78.2%) and 46 of 52 (88.4%), respectively (P < 0.01). High intensity (strong positive)/high proportion (more than 50%) staining seen in CIS and cervical cancer tissue samples was 45 of 55 (81.8%)/22 of 55 (40.0%) and 50 of 52 (96.2%)/31 of 52 (59.7%), respectively (P = 0.029 and P = 0.054). There was no significant correlation between the immunostaining score and stage and the immunostaining score and survival. CONCLUSION:Osteopontin may have a potential use as a diagnostic factor for cervical cancer and osteopontin expression is closely correlated with carcinogenesis and invasion of cervical cancer.
Authors: Danny T M Leung; Pak-Leong Lim; Tak-Hong Cheung; Raymond R Y Wong; So-Fan Yim; Margaret H L Ng; Frankie C H Tam; Tony K H Chung; Yick-Fu Wong Journal: PLoS One Date: 2016-08-05 Impact factor: 3.240
Authors: Syed A Hussain; Daniel H Palmer; Wing-Kin Syn; Joseph J Sacco; Richard M D Greensmith; Taha Elmetwali; Vijay Aachi; Bryony H Lloyd; Puthen V Jithesh; John Arrand; Darren Barton; Jawaher Ansari; D Ross Sibson; Nicholas D James Journal: Int J Oncol Date: 2017-03-02 Impact factor: 5.650
Authors: Suzanne Bartholf DeWitt; Sarah Hoskinson Plumlee; Hailey E Brighton; Dharshan Sivaraj; E J Martz; Maryam Zand; Vardhman Kumar; Maya U Sheth; Warren Floyd; Jacob V Spruance; Nathan Hawkey; Shyni Varghese; Jianhua Ruan; David G Kirsch; Jason A Somarelli; Ben Alman; William C Eward Journal: JCI Insight Date: 2022-09-08