An outbreak of toxoplasmosis in pregnant women in northern Québec.

An ongoing screening program for toxoplasmosis identified a cluster of four women from northern Québec who, over a 4-month period, seroconverted during their pregnancy. An epidemiologic investigation was carried out in an attempt to identify the source of this infection. All potential risk factors were assessed by a questionnaire administered to 22 Inuit women who had delivered babies in the previous year. Seroconversion was significantly associated with skinning of animals for fur (P = .015) and frequent consumption of caribou meat (P = .034). Compared to seronegative women, women who were seropositive were more than four times more likely to have eaten dried seal meat (P = .067), more than six times more likely to have eaten seal liver (P = .064), and more than eight times more likely to have consumed raw caribou meat more than once per week (P = .054). These observations have contributed to the development of guidelines for the prevention of toxoplasmosis in seronegative pregnant women in this arctic region.