Literature DB >> 19694467

Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease.

Anthony F Kreft1, Robert Martone, Alexander Porte.   

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Year:  2009        PMID： 19694467     DOI： 10.1021/jm900188z

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  30 in total

1.  Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence.

Authors:  Candace A Gilbert; Marie-Claire Daou; Richard P Moser; Alonzo H Ross
Journal:  Cancer Res       Date:  2010-08-24       Impact factor: 12.701

2.  Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphology.

Authors:  Cyrus K Bett; Johnpeter N Ngunjiri; Wilson K Serem; Krystal R Fontenot; Robert P Hammer; Robin L McCarley; Jayne C Garno
Journal:  ACS Chem Neurosci       Date:  2010-07-08       Impact factor: 4.418

Review 3.  Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.

Authors:  Bart De Strooper; Takeshi Iwatsubo; Michael S Wolfe
Journal:  Cold Spring Harb Perspect Med       Date:  2012-01       Impact factor: 6.915

Review 4.  Targeting γ-secretase in breast cancer.

Authors:  Jianxun Han; Qiang Shen
Journal:  Breast Cancer (Dove Med Press)       Date:  2012-06-21

5.  Rationalizing lead optimization by consensus 2D- CoMFA CoMSIA GRIND (3D) QSAR guided fragment hopping in search of γ-secretase inhibitors.

Authors:  Prabu Manoharan; Nanda Ghoshal
Journal:  Mol Divers       Date:  2012-08-14       Impact factor: 2.943

6.  BMS-708,163 targets presenilin and lacks notch-sparing activity.

Authors:  Christina J Crump; Suita V Castro; Feng Wang; Nikolay Pozdnyakov; T Eric Ballard; Sangram S Sisodia; Kelly R Bales; Douglas S Johnson; Yue-Ming Li
Journal:  Biochemistry       Date:  2012-09-04       Impact factor: 3.162

7.  Has inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data.

Authors:  Camilla Niva; Joanna Parkinson; Fredrik Olsson; Erno van Schaick; Johan Lundkvist; Sandra A G Visser
Journal:  Eur J Clin Pharmacol       Date:  2013-01-04       Impact factor: 2.953

8.  Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside.

Authors:  Nathan O Fuller; Jed L Hubbs; Wesley F Austin; Steffen P Creaser; Timothy D McKee; Robyn M B Loureiro; Barbara Tate; Weiming Xia; Jeffrey L Ives; Mark A Findeis; Brian S Bronk
Journal:  ACS Med Chem Lett       Date:  2012-08-29       Impact factor: 4.345

9.  Population PKPD modeling of BACE1 inhibitor-induced reduction in Aβ levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.

Authors:  Juliette Janson; Susanna Eketjäll; Karin Tunblad; Fredrik Jeppsson; Stefan Von Berg; Camilla Niva; Ann-Cathrin Radesäter; Johanna Fälting; Sandra A G Visser
Journal:  Pharm Res       Date:  2013-10-03       Impact factor: 4.200

10.  A novel high throughput 1536-well Notch1 γ -secretase AlphaLISA assay.

Authors:  De-Ming Chau; David Shum; Constantin Radu; Bhavneet Bhinder; David Gin; M Lane Gilchrist; Hakim Djaballah; Yue-Ming Li
Journal:  Comb Chem High Throughput Screen       Date:  2013-07       Impact factor: 1.339
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