Literature DB >> 19693444

Probing key targets in insulin signaling and adipogenesis using a methanolic extract of Costus pictus and its bioactive molecule, methyl tetracosanoate.

Kusampudi Shilpa1, Kadapakkam Nandabalan Sangeetha, Velusamy Shanmuganathan Muthusamy, Sundaresan Sujatha, Baddireddi Subadhra Lakshmi.   

Abstract

A methanolic extract of Costus pictus (CPME) showed optimum anti-diabetic activity at 100 ng/ml. Bioactivity-guided purification of CPME led to the isolation of methyl tetracosanoate (MT) which showed an optimum glucose uptake at 1 ng/ml. CPME at 10 mug/ml inhibited adipogenesis whereas fully differentiated adipocytes exhibited a 3-fold increase in lipid accumulation compared to pre-adipocytes. Gene and protein expression of key targets in insulin signaling and adipogenesis pathway revealed that CPME exhibited anti-diabetic activity along with anti-adipogenic activity whereas MT demonstrated only anti-diabetic activity.

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Year:  2009        PMID： 19693444     DOI： 10.1007/s10529-009-0105-3

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  7 in total

1.  Costus root granules improve ulcerative colitis through regulation of TGF-β mediation of the PI3K/AKT signaling pathway.

Authors:  Xiaohong Wang; Dan Li; Yong Zhang; Shuang Wu; Fang Tang
Journal:  Exp Ther Med       Date:  2018-03-09       Impact factor: 2.447

2.  An In Vitro Model to Probe the Regulation of Adipocyte Differentiation under Hyperglycemia.

Authors:  Kusampudi Shilpa; Thangaraj Dinesh; Baddireddi Subhadra Lakshmi
Journal:  Diabetes Metab J       Date:  2013-06-14       Impact factor: 5.376

3.  Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity.

Authors:  Kalathookunnel Antony Antu; Mariam Philip Riya; Arvind Mishra; Karunakaran S Anilkumar; Chandrasekharan K Chandrakanth; Akhilesh K Tamrakar; Arvind K Srivastava; K Gopalan Raghu
Journal:  PLoS One       Date:  2014-09-03       Impact factor: 3.240

Review 4.  Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development.

Authors:  Safaet Alam; Md Moklesur Rahman Sarker; Taposhi Nahid Sultana; Md Nafees Rahman Chowdhury; Mohammad A Rashid; Nusrat Islam Chaity; Chao Zhao; Jianbo Xiao; Elsayed E Hafez; Shah Alam Khan; Isa Naina Mohamed
Journal:  Front Endocrinol (Lausanne)       Date:  2022-02-24       Impact factor: 5.555

5.  Next generation sequencing and de novo transcriptome analysis of Costus pictus D. Don, a non-model plant with potent anti-diabetic properties.

Authors:  Ramasamy S Annadurai; Vasanthan Jayakumar; Raja C Mugasimangalam; Mohan A V S K Katta; Sanchita Anand; Sreeja Gopinathan; Santosh Prasad Sarma; Sunjay Jude Fernandes; Nandita Mullapudi; S Murugesan; Sudha Narayana Rao
Journal:  BMC Genomics       Date:  2012-11-23       Impact factor: 3.969

6.  Role of STAT3 Phosphorylation in Ethanol-Mediated Proliferation of Breast Cancer Cells.

Authors:  Poornima Devi Narayanan; Sangeetha Kadapakkam Nandabalan; Lakshmi Subhadra Baddireddi
Journal:  J Breast Cancer       Date:  2016-06-24       Impact factor: 3.588

7.  Current trends in small molecule discovery targeting key cellular signaling events towards the combined management of diabetes and obesity.

Authors:  Kadapakkam Nandabalan Sangeetha; Sundaresan Sujatha; Velusamy Shanmuganathan Muthusamy; Singaravel Anand; Kusampudi Shilpa; Posa Jyothi Kumari; Baskaran Sarathkumar; Gopal Thiyagarajan; Baddireddi Subhadra Lakshmi
Journal:  Bioinformation       Date:  2017-12-31
  7 in total

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