Literature DB >> 19692991

The sickness unto Deaf.

James M Gardner, Mark S Anderson.   

Abstract

While promiscuous expression of tissue-specific antigens (TSAs) in the thymus is essential for self-tolerance, immunologically relevant TSA expression may also occur in the secondary lymphoid organs. A new study links the transcriptional regulator Deaf1 with altered TSA expression in the secondary lymphoid organs and autoimmune diabetes.

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Year:  2009        PMID： 19692991      PMCID： PMC2773699          DOI： 10.1038/ni0909-934

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  15 in total

1.  Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

Authors:  J Derbinski; A Schulte; B Kyewski; L Klein
Journal:  Nat Immunol       Date:  2001-11       Impact factor: 25.606

2.  Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice.

Authors:  Keiichi Kodama; Atul J Butte; Remi J Creusot; Leon Su; Deqiao Sheng; Mark Hartnett; Hideyuki Iwai; Luis R Soares; C Garrison Fathman
Journal:  Clin Immunol       Date:  2008-09-17       Impact factor: 3.969

3.  Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators.

Authors:  T M Sugihara; I Bach; C Kioussi; M G Rosenfeld; B Andersen
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

4.  Projection of an immunological self shadow within the thymus by the aire protein.

Authors:  Mark S Anderson; Emily S Venanzi; Ludger Klein; Zhibin Chen; Stuart P Berzins; Shannon J Turley; Harald von Boehmer; Roderick Bronson; Andrée Dierich; Christophe Benoist; Diane Mathis
Journal:  Science       Date:  2002-10-10       Impact factor: 47.728

5.  Positional cloning of the APECED gene.

Authors:  K Nagamine; P Peterson; H S Scott; J Kudoh; S Minoshima; M Heino; K J Krohn; M D Lalioti; P E Mullis; S E Antonarakis; K Kawasaki; S Asakawa; F Ito; N Shimizu
Journal:  Nat Genet       Date:  1997-12       Impact factor: 38.330

6.  Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein.

Authors:  S J Antonia; T Geiger; J Miller; R A Flavell
Journal:  Int Immunol       Date:  1995-05       Impact factor: 4.823

7.  T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

Authors:  C Jolicoeur; D Hanahan; K M Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-05       Impact factor: 11.205

8.  Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1.

Authors:  Kyungmin Hahm; Eleanor Y M Sum; Yuko Fujiwara; Geoffrey J Lindeman; Jane E Visvader; Stuart H Orkin
Journal:  Mol Cell Biol       Date:  2004-03       Impact factor: 4.272

9.  Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein.

Authors:  J I Huggenvik; R J Michelson; M W Collard; A J Ziemba; P Gurley; K A Mowen
Journal:  Mol Endocrinol       Date:  1998-10

10.  DEAF-1, a novel protein that binds an essential region in a Deformed response element.

Authors:  C T Gross; W McGinnis
Journal:  EMBO J       Date:  1996-04-15       Impact factor: 11.598
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  2 in total

1.  A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis.

Authors:  Carlos Riveros; Drew Mellor; Kaushal S Gandhi; Fiona C McKay; Mathew B Cox; Regina Berretta; S Yahya Vaezpour; Mario Inostroza-Ponta; Simon A Broadley; Robert N Heard; Stephen Vucic; Graeme J Stewart; David W Williams; Rodney J Scott; Jeanette Lechner-Scott; David R Booth; Pablo Moscato
Journal:  PLoS One       Date:  2010-12-01       Impact factor: 3.240

2.  CNV Analysis Associates AKNAD1 with Type-2 Diabetes in Jordan Subpopulations.

Authors:  Rana Dajani; Jin Li; Zhi Wei; Joseph T Glessner; Xiao Chang; Christopher J Cardinale; Renata Pellegrino; Tiancheng Wang; Nancy Hakooz; Yousef Khader; Amina Sheshani; Duaa Zandaki; Hakon Hakonarson
Journal:  Sci Rep       Date:  2015-08-21       Impact factor: 4.379
  2 in total

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