| Literature DB >> 19692247 |
Stefan Tasler1, Oliver Müller, Tanja Wieber, Thomas Herz, Stefano Pegoraro, Wael Saeb, Martin Lang, Rolf Krauss, Frank Totzke, Ute Zirrgiebel, Jan E Ehlert, Michael H G Kubbutat, Christoph Schächtele.
Abstract
Based on an (aminoaryl)benzothiazole quinazoline hit structure for kinase inhibition, a systematic optimization program resulted in a lead structure allowing for inhibitory activities in cellular phosphorylation assays in the low nanomolar range.Entities:
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Year: 2009 PMID： 19692247 DOI： 10.1016/j.bmc.2009.07.047
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641