| Literature DB >> 19692241 |
Mark D Andrews1, Martin P Green, Charlotte M N Allerton, David V Batchelor, Julian Blagg, Alan D Brown, David W Gordon, Gordon McMurray, Daniel J Millns, Carly L Nichols, Lesa Watson.
Abstract
This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT(2C) agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT(2A) and 5-HT(2B) receptors. Compound 11 was active in in vivo models of stress urinary incontinence.Entities:
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Year: 2009 PMID： 19692241 DOI： 10.1016/j.bmcl.2009.07.133
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823