PURPOSE: To investigate the abnormal diffusion in cerebral white matter and its relationship with the olfactory dysfunction in patients with Parkinson's disease (PD) through diffusion tensor imaging (DTI). MATERIALS AND METHODS: Diffusion tensor imaging of the cerebrum was performed in 25 patients with Parkinson's disease and 25 control subjects matched for age and sex. Differences in fractional anisotropy (FA) and mean diffusivity (MD) between these two groups were studied by voxel-based analysis of the DTI data. Correlations between diffusion indices and the olfactory function in PD patients were evaluated using the multiple regression model after controlling for the duration of the disease, Unified Parkinson's Disease Rating Sale (UPDRS), and age. RESULTS: The damaged white and gray matter showed decreased FA or increased MD, localized bilaterally in the cerebellar and orbitofrontal cortex. In addition, in PD patients there was a positive correlation between FA values in the white matter of the left cerebellum and the thresholds of olfactory identification (TOI) and a negative correlation between MD values in the white matter of right cerebellum and the TOI. CONCLUSION: In patients with PD, there was disruption in the cerebellar white matter which may play an important role in the olfactory dysfunction in patients with Parkinson's disease.
PURPOSE: To investigate the abnormal diffusion in cerebral white matter and its relationship with the olfactory dysfunction in patients with Parkinson's disease (PD) through diffusion tensor imaging (DTI). MATERIALS AND METHODS: Diffusion tensor imaging of the cerebrum was performed in 25 patients with Parkinson's disease and 25 control subjects matched for age and sex. Differences in fractional anisotropy (FA) and mean diffusivity (MD) between these two groups were studied by voxel-based analysis of the DTI data. Correlations between diffusion indices and the olfactory function in PDpatients were evaluated using the multiple regression model after controlling for the duration of the disease, Unified Parkinson's Disease Rating Sale (UPDRS), and age. RESULTS: The damaged white and gray matter showed decreased FA or increased MD, localized bilaterally in the cerebellar and orbitofrontal cortex. In addition, in PDpatients there was a positive correlation between FA values in the white matter of the left cerebellum and the thresholds of olfactory identification (TOI) and a negative correlation between MD values in the white matter of right cerebellum and the TOI. CONCLUSION: In patients with PD, there was disruption in the cerebellar white matter which may play an important role in the olfactory dysfunction in patients with Parkinson's disease.
Authors: Vincent Pozorski; Jennifer M Oh; Nagesh Adluru; Andrew P Merluzzi; Frances Theisen; Ozioma Okonkwo; Amy Barzgari; Stephanie Krislov; Jitka Sojkova; Barbara B Bendlin; Sterling C Johnson; Andrew L Alexander; Catherine L Gallagher Journal: Hum Brain Mapp Date: 2018-06-27 Impact factor: 5.038
Authors: Eve M Dumas; Simon J A van den Bogaard; Margot E Ruber; Ralf R Reilman; Julie C Stout; David Craufurd; Stephen L Hicks; Chris Kennard; Sarah J Tabrizi; Mark A van Buchem; Jeroen van der Grond; Raymund A C Roos Journal: Hum Brain Mapp Date: 2011-01-24 Impact factor: 5.038
Authors: Trina Mitchell; Derek B Archer; Winston T Chu; Stephen A Coombes; Song Lai; Bradley J Wilkes; Nikolaus R McFarland; Michael S Okun; Mieniecia L Black; Ellen Herschel; Tanya Simuni; Cynthia Comella; Tao Xie; Hong Li; Todd B Parrish; Ajay S Kurani; Daniel M Corcos; David E Vaillancourt Journal: Hum Brain Mapp Date: 2019-08-12 Impact factor: 5.038
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Authors: Christopher W Hess; Edward Ofori; Umer Akbar; Michael S Okun; David E Vaillancourt Journal: Curr Neurol Neurosci Rep Date: 2013-11 Impact factor: 5.081