BACKGROUND: Conventional treatment for nasal augmentation utilizes autologous grafts, allografts, or synthetic implants such as silicon implants. Silicon implants could protrude/expose or induce nasal bone resorption. Autologous grafts are usually associated with donor site morbidity and the volume of harvested tissue is limited. We had developed a new method for nasal augmentation using cultured autologous chondrocytes (CAC). The current report presents the results of a study using that method with a larger number of patients and an improved graft technique for the nasal tip. METHODS: Approximately 1 cm2 of cartilage was harvested from the auricular concha and treated with collagenase, and then chondrocytes were obtained. In our multilayer culture system the chondrocytes formed immature cartilaginous tissues with a gelatinous chondroid matrix. They were injection-grafted into the subcutaneous pocket of the nasal dorsum. RESULTS: The chondrocytes with a gelatinous chondroid matrix change from a soft gel to hard neocartilage tissue within 2 to 3 weeks and then stabilize. The authors have used this procedure over a 6-year period on 75 cases: 58 secondary augmentation rhinoplasties following silicon implantation and 17 primary augmentation cases. The results have been satisfactory and long-lasting. CONCLUSION: Grafting of CAC is an optional method for nasal augmentation and could be used for a wide range of facial augmentation cases.
BACKGROUND: Conventional treatment for nasal augmentation utilizes autologous grafts, allografts, or synthetic implants such as silicon implants. Silicon implants could protrude/expose or induce nasal bone resorption. Autologous grafts are usually associated with donor site morbidity and the volume of harvested tissue is limited. We had developed a new method for nasal augmentation using cultured autologous chondrocytes (CAC). The current report presents the results of a study using that method with a larger number of patients and an improved graft technique for the nasal tip. METHODS: Approximately 1 cm2 of cartilage was harvested from the auricular concha and treated with collagenase, and then chondrocytes were obtained. In our multilayer culture system the chondrocytes formed immature cartilaginous tissues with a gelatinous chondroid matrix. They were injection-grafted into the subcutaneous pocket of the nasal dorsum. RESULTS: The chondrocytes with a gelatinous chondroid matrix change from a soft gel to hard neocartilage tissue within 2 to 3 weeks and then stabilize. The authors have used this procedure over a 6-year period on 75 cases: 58 secondary augmentation rhinoplasties following silicon implantation and 17 primary augmentation cases. The results have been satisfactory and long-lasting. CONCLUSION: Grafting of CAC is an optional method for nasal augmentation and could be used for a wide range of facial augmentation cases.
Authors: Renata Giardini-Rosa; Paulo P Joazeiro; Kathryn Thomas; Kristina Collavino; Joanna Weber; Stephen D Waldman Journal: Tissue Eng Part A Date: 2014-01-21 Impact factor: 3.845
Authors: Renata G Rosa; Paulo P Joazeiro; Juares Bianco; Manuela Kunz; Joanna F Weber; Stephen D Waldman Journal: PLoS One Date: 2014-08-15 Impact factor: 3.240
Authors: Alan Tseng; Irina Pomerantseva; Michael J Cronce; Anya M Kimura; Craig M Neville; Mark A Randolph; Joseph P Vacanti; Cathryn A Sundback Journal: Cartilage Date: 2014-10 Impact factor: 4.634