Literature DB >> 19690532

A division of labor: asymmetric roles for GPCR subunits in receptor dimers.

Peter Zylbergold1, Terence E Hébert.   

Abstract

The functional architecture of dimeric or oligomeric GPCR signaling remains incompletely understood. Using a clever combination of receptor-G protein fusions and various receptor mutations, new research provides a glimpse into how oligomers might be arranged with respect to the G proteins they interact with.

Mesh：

Substances：

Year:  2009        PMID： 19690532     DOI： 10.1038/nchembio0909-608

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  11 in total

Review 1.  Allosteric functioning of dimeric class C G-protein-coupled receptors.

Authors:  J-P Pin; J Kniazeff; J Liu; V Binet; C Goudet; P Rondard; L Prézeau
Journal:  FEBS J       Date:  2005-06       Impact factor: 5.542

Review 2.  Functional selectivity through protean and biased agonism: who steers the ship?

Authors:  Terry Kenakin
Journal:  Mol Pharmacol       Date:  2007-09-27       Impact factor: 4.436

Review 3.  Molecular basis for amino acid sensing by family C G-protein-coupled receptors.

Authors:  P Wellendorph; H Bräuner-Osborne
Journal:  Br J Pharmacol       Date:  2009-03       Impact factor: 8.739

4.  A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.

Authors:  Matthew R Whorton; Michael P Bokoch; Søren G F Rasmussen; Bo Huang; Richard N Zare; Brian Kobilka; Roger K Sunahara
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-23       Impact factor: 11.205

5.  Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein.

Authors:  Jean-Louis Banères; Joseph Parello
Journal:  J Mol Biol       Date:  2003-06-13       Impact factor: 5.469

6.  Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer.

Authors:  Matthew R Whorton; Beata Jastrzebska; Paul S-H Park; Dimitrios Fotiadis; Andreas Engel; Krzysztof Palczewski; Roger K Sunahara
Journal:  J Biol Chem       Date:  2007-11-22       Impact factor: 5.157

7.  Heterooligomers of the muscarinic receptor and G proteins purified from porcine atria.

Authors:  Amy W-S Ma; Asha B Pawagi; James W Wells
Journal:  Biochem Biophys Res Commun       Date:  2008-07-02       Impact factor: 3.575

8.  Recovery of oligomers and cooperativity when monomers of the M2 muscarinic cholinergic receptor are reconstituted into phospholipid vesicles.

Authors:  Amy W-S Ma; Dar'ya S Redka; Luca F Pisterzi; Stéphane Angers; James W Wells
Journal:  Biochemistry       Date:  2007-06-07       Impact factor: 3.162

Review 9.  The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.

Authors:  Denis J Dupré; Mélanie Robitaille; R Victor Rebois; Terence E Hébert
Journal:  Annu Rev Pharmacol Toxicol       Date:  2009       Impact factor: 13.820

10.  Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

Authors:  Yang Han; Irina S Moreira; Eneko Urizar; Harel Weinstein; Jonathan A Javitch
Journal:  Nat Chem Biol       Date:  2009-08-02       Impact factor: 15.040
View more
  3 in total

1.  Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors.

Authors:  Cody J Lensing; Katie T Freeman; Sathya M Schnell; Robert C Speth; Adam T Zarth; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2018-05-09       Impact factor: 7.446

2.  Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization.

Authors:  Min Wang; Lin Pei; Paul J Fletcher; Shitij Kapur; Philip Seeman; Fang Liu
Journal:  Mol Brain       Date:  2010-09-02       Impact factor: 4.041

Review 3.  From atomic structures to neuronal functions of g protein-coupled receptors.

Authors:  Krzysztof Palczewski; Tivadar Orban
Journal:  Annu Rev Neurosci       Date:  2013-05-15       Impact factor: 12.449
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.