Literature DB >> 196896

Effect of vinblastine on pancreatic enzymes secretion induced by cyclic nucleotide derivatives.

C Stock, J F Launary, J F Grenier, H Bauduin.   

Abstract

Vinblastine did not affect the basal secretion of enzymes from the rat pancreas, but it potentiates the secretory response to dibutyryl cyclic AMP. This potentiation is confirmed by the observation of numerous pictures of exocytosis at the apical part of the acinar cell. Dibutyryl cyclic GMP by itself, or associated with vinblastine, failed to modify the spontaneous release of enzymes or the secretion induced by dibutyryl cyclic AMP.

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Year:  1977        PMID: 196896     DOI: 10.1007/bf01945973

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  15 in total

1.  Absence of effects of dibutyryl cyclic guanosine 3',5'-monophosphate on release of alpha-amylase, 45Ca efflux, and protein synthesis in rat pancreas in vitro.

Authors:  S Heisler; G Grondin
Journal:  Experientia       Date:  1975-08-15

2.  Role of cyclic 3',5'-amp in the action of physiological secretagogues on the metabolism of rat pancreas in vitro.

Authors:  H Bauduin; L Rochus; D Vincent; J E Dumont
Journal:  Biochim Biophys Acta       Date:  1971-10

3.  Techniques for measuring amylase secretion from pieces of mouse pancreas.

Authors:  A Danielsson
Journal:  Anal Biochem       Date:  1974-05       Impact factor: 3.365

4.  In vitro and in vivo effects of pancreozymin, urecholine, and cyclic AMP on rat pancreas.

Authors:  J A Morisset; P D Webster
Journal:  Am J Physiol       Date:  1971-01

5.  Energy sources for protein synthesis and enzymatic secretion in rat pancreas in vitro.

Authors:  H Bauduin; M Colin; J E Dumont
Journal:  Biochim Biophys Acta       Date:  1969-02-18

6.  [The secretagogic effect of dibutyryl cyclic adenosine monophosphate on the rat exocrine pancreas].

Authors:  C Stock; D Vincent; H Bauduin; J Grenier
Journal:  Arch Int Physiol Biochim       Date:  1976-04

Review 7.  Microtubules, cyclic AMP, calcium, and secretion.

Authors:  E Gillespie
Journal:  Ann N Y Acad Sci       Date:  1975-06-30       Impact factor: 5.691

8.  Cyclic AMP in pancreatic acinar cells: effects of gastrointestinal hormones.

Authors:  J D Gardner; T P Conlon; T D Adams
Journal:  Gastroenterology       Date:  1976-01       Impact factor: 22.682

9.  Cellular cyclic nucleotides and enzyme secretion in the pancreatic acinar cell.

Authors:  A Haymovits; G A Scheele
Journal:  Proc Natl Acad Sci U S A       Date:  1976-01       Impact factor: 11.205

10.  Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. II. Inhibition of antimicrotubular agents.

Authors:  J Seybold; W Bieger; H F Kern
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1975-11-28
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