Literature DB >> 19689414

The intriguing phospholipases A2 homologues: relevant structural features on myotoxicity and catalytic inactivity.

Juliana I dos Santos1, Carlos A H Fernandes, Angelo J Magro, Marcos R M Fontes.   

Abstract

Phospholipases A(2) homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.

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Year:  2009        PMID： 19689414     DOI： 10.2174/092986609788923310

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  8 in total

1.  Crystallization and preliminary X-ray crystallographic studies of a Lys49-phospholipase A2 homologue from Bothrops pirajai venom complexed with rosmarinic acid.

Authors:  Juliana I dos Santos; Norival A Santos-Filho; Andreimar M Soares; Marcos R M Fontes
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-05-27

2.  Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain.

Authors:  Mariana Cintra-Francischinelli; Paola Caccin; Angela Chiavegato; Paola Pizzo; Giorgio Carmignoto; Yamileth Angulo; Bruno Lomonte; José María Gutiérrez; Cesare Montecucco
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-26       Impact factor: 11.205

3.  Crystallization and preliminary X-ray diffraction analysis of three myotoxic phospholipases A2 from Bothrops brazili venom.

Authors:  Carlos A H Fernandes; Elaine C G Gartuzo; Ivan Pagotto; Edson J Comparetti; Salomón Huancahuire-Vega; Luis Alberto Ponce-Soto; Tássia R Costa; Sergio Marangoni; Andreimar M Soares; Marcos R M Fontes
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-07-31

4.  Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA₂ inhibition.

Authors:  Juliana I Dos Santos; Fábio F Cardoso; Andreimar M Soares; Maeli Dal Pai Silva; Márcia Gallacci; Marcos R M Fontes
Journal:  PLoS One       Date:  2011-12-21       Impact factor: 3.240

5.  Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?

Authors:  Diana Mora-Obando; Cecilia Díaz; Yamileth Angulo; José María Gutiérrez; Bruno Lomonte
Journal:  PeerJ       Date:  2014-09-16       Impact factor: 2.984

6.  Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo.

Authors:  Diana Mora-Obando; Julián Fernández; Cesare Montecucco; José María Gutiérrez; Bruno Lomonte
Journal:  PLoS One       Date:  2014-10-07       Impact factor: 3.240

7.  Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom.

Authors:  Barbara S Soares; Surza Lucia G Rocha; Viviane A Bastos; Diogo B Lima; Paulo C Carvalho; Fabio C Gozzo; Borries Demeler; Tayler L Williams; Janelle Arnold; Amy Henrickson; Thomas J D Jørgensen; Tatiana A C B Souza; Jonas Perales; Richard H Valente; Bruno Lomonte; Francisco Gomes-Neto; Ana Gisele C Neves-Ferreira
Journal:  Front Mol Biosci       Date:  2022-01-27

8.  Structural and phylogenetic studies with MjTX-I reveal a multi-oligomeric toxin--a novel feature in Lys49-PLA2s protein class.

Authors:  Guilherme H M Salvador; Carlos A H Fernandes; Angelo J Magro; Daniela P Marchi-Salvador; Walter L G Cavalcante; Roberto M Fernandez; Márcia Gallacci; Andreimar M Soares; Cristiano L P Oliveira; Marcos R M Fontes
Journal:  PLoS One       Date:  2013-04-03       Impact factor: 3.240
  8 in total

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