Literature DB >> 196891

The effect of pyrophosphate and diphosphonates on calcium transport in red cells.

R Felix, H Fleisch.   

Abstract

The effect of 0.5 mM pyrophosphate (PPi), disodium ethane-4-hydroxy-1,1-diphosphonate (EHDP) and disodium dichloromethane diphosphonate (Cl2MDP) on the ATP-dependent Ca2+ extrusion from the human red cell ghosts was studied. PPi and Cl2MDP had no effect, when introduced into the cells or added outside to the medium. EHDP slightly increased the calcium concentration in the released cells and slightly decreased the rate constant of the calcium transport, having opposite effects when it was inside or outside the cells. PPi and the 2 diphosphonates were not found to move easily across the red cell membrane.

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Year:  1977        PMID： 196891     DOI： 10.1007/bf01945933

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Mechanisms of calcification: role of collagen, polyphosphates, and phosphatase.

Authors:  H FLEISH; W F NEUMAN
Journal:  Am J Physiol       Date:  1961-06

2.  A comparison of three methods for the assay of hemoglobin.

Authors:  A KUMLIEN; K G PAUL; S LJUNGBERG
Journal:  Scand J Clin Lab Invest       Date:  1960       Impact factor: 1.713

3.  Yeast inorganic pyrophosphatase. 3. Kinetics of Ca 2+ inhibition.

Authors:  O A Moe; L G Butler
Journal:  J Biol Chem       Date:  1972-11-25       Impact factor: 5.157

4.  The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo.

Authors:  H A Fleisch; R G Russell; S Bisaz; R C Mühlbauer; D A Williams
Journal:  Eur J Clin Invest       Date:  1970-03       Impact factor: 4.686

5.  The effect of in vivo treatment with EHDP and/or 1,25-DHCC on calcium uptake and release in isolated kidney mitochondria.

Authors:  D F Guilland; H Fleisch
Journal:  Biochem Biophys Res Commun       Date:  1974-12-11       Impact factor: 3.575

6.  Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis.

Authors:  H Fleisch; R G Russell; F Straumann
Journal:  Nature       Date:  1966-11-26       Impact factor: 49.962

7.  Erythrocyte neutral inorganic pyrophosphatase in pseudogout.

Authors:  D J McCarty; P F Pepe
Journal:  J Lab Clin Med       Date:  1972-02

8.  ATP-dependent Ca++-extrusion from human red cells.

Authors:  H J Schatzmann
Journal:  Experientia       Date:  1966-06-15

9.  Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats.

Authors:  R Schenk; W A Merz; R Mühlbauer; R G Russell; H Fleisch
Journal:  Calcif Tissue Res       Date:  1973-03-12

10.  Calcium movements across the membrane of human red cells.

Authors:  H J Schatzmann; F F Vincenzi
Journal:  J Physiol       Date:  1969-04       Impact factor: 5.182
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  3 in total

1.  Proceedings of a symposium on crystal-related arthropathies. 22 October and 23 October, 1982, Bristol Polytechnic, Bristol.

Authors: 
Journal:  Ann Rheum Dis       Date:  1983-08       Impact factor: 19.103

Review 2.  Pathogenesis of chondrocalcinosis and pseudogout. Metabolism of inorganic pyrophosphate and production of calcium pyrophosphate dihydrate crystals.

Authors:  A Caswell; D F Guilland-Cumming; P R Hearn; M K McGuire; R G Russell
Journal:  Ann Rheum Dis       Date:  1983-08       Impact factor: 19.103

3.  Pyrophosphohydrolase activity and inorganic pyrophosphate content of cultured human skin fibroblasts. Elevated levels in some patients with calcium pyrophosphate dihydrate deposition disease.

Authors:  L M Ryan; R L Wortmann; B Karas; M P Lynch; D J McCarty
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808
  3 in total

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