Literature DB >> 1968900

Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

T Aoyagi1, S Yoshida, Y Nakamura, Y Shigihara, M Hamada, T Takeuchi.   

Abstract

Probestin has been isolated as part of a program designed to find microorganism-produced inhibitors of aminopeptidase M from Streptomyces azureus MH663-2F6. It was purified by use of column chromatography of Amberlite XAD-4, silica gel, YMC-gel, Toyopearl HW-40, YMC D-ODS-5 (HPLC) and then isolated as colorless powders. Probestin is competitive with the substrate, and the inhibition constant (Ki) of it was 1.9 x 10(-8) M.

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Year:  1990        PMID： 1968900     DOI： 10.7164/antibiotics.43.143

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

1.  Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo.

Authors:  Gopal Pathuri; Andria F Hedrick; Bryan C Disch; John T Doan; Michael A Ihnat; Vibhudutta Awasthi; Hariprasad Gali
Journal:  Bioconjug Chem       Date:  2011-12-20       Impact factor: 4.774

2.  Induction of the membrane alanyl aminopeptidase gene and surface expression in human T-cells by mitogenic activation.

Authors:  U Lendeckel; T Wex; D Reinhold; T Kähne; K Frank; J Faust; K Neubert; S Ansorge
Journal:  Biochem J       Date:  1996-11-01       Impact factor: 3.857

3.  Evaluation of (99m)Tc-probestin SPECT as a novel technique for noninvasive imaging of kidney aminopeptidase N expression.

Authors:  Gopal Pathuri; Venkateshwar Madka; Andria F Hedrick; Stanley A Lightfoot; Vibhudutta Awasthi; Benjamin D Cowley; Chinthalapally V Rao; Hariprasad Gali
Journal:  Mol Pharm       Date:  2014-07-10       Impact factor: 4.939

Review 4.  Metallo-aminopeptidase inhibitors.

Authors:  Artur Mucha; Marcin Drag; John P Dalton; Paweł Kafarski
Journal:  Biochimie       Date:  2010-05-10       Impact factor: 4.079

Review 5.  Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

Authors:  Brigitte Bauvois; Daniel Dauzonne
Journal:  Med Res Rev       Date:  2006-01       Impact factor: 12.944

6.  Development of pyrazoline-based derivatives as aminopeptidase N inhibitors to overcome cancer invasion and metastasis.

Authors:  Jiangying Cao; Chunlong Zhao; Hang Dong; Qifu Xu; Yingjie Zhang
Journal:  RSC Adv       Date:  2021-06-17       Impact factor: 3.361

7.  Inhibition of aminopeptidases N, A and W. A re-evaluation of the actions of bestatin and inhibitors of angiotensin converting enzyme.

Authors:  S Tieku; N M Hooper
Journal:  Biochem Pharmacol       Date:  1992-11-03       Impact factor: 5.858

8.  Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors.

Authors:  Jiajia Mou; Hao Fang; Fanbo Jing; Qiang Wang; Yingzi Liu; Huawei Zhu; Luqing Shang; Xuejian Wang; Wenfang Xu
Journal:  Bioorg Med Chem       Date:  2009-05-03       Impact factor: 3.641

9.  Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor.

Authors:  Gopal Pathuri; Jessica E Thorpe; Bryan C Disch; Lora C Bailey-Downs; Michael A Ihnat; Hariprasad Gali
Journal:  Bioorg Med Chem Lett       Date:  2013-04-23       Impact factor: 2.823
  9 in total

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