AIMS AND OBJECTIVES: Preeclampsia and eclampsia are pregnancy complications with serious consequences for mother and infant. Uncontrolled lipid peroxidation may play an important role in the pathophysiology of preeclampsia and eclampsia by causing vascular endothelial cell dysfunction. Antioxidants serve to control lipid peroxidation. We attempted to ascertain whether antioxidant protective mechanisms are diminished in women with preeclampsia and eclampsia. MATERIALS AND METHODS: Lipid peroxidation and antioxidant markers were assayed in 25 healthy non-pregnant women as a control group, 25 third trimester normal pregnant women, 25 preeclamptic and 25 eclamptic patients of the same trimester by standard spectrophotometer methods. RESULTS: In preeclampsia and eclampsia malondialdehyde, a product of lipid peroxidation, was significantly increased while enzymatic antioxidants like superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase were significantly reduced as compared to normal pregnant women and non-pregnant controls. CONCLUSION: Lipid peroxidation is an important factor in the pathogenesis of preeclampsia and eclampsia. The decrease in antioxidants is probably due to a compensatory nature responding to the increased lipid peroxide load in preeclamptic and eclamptic patients and may indicate the severity of the disease.
AIMS AND OBJECTIVES:Preeclampsia and eclampsia are pregnancy complications with serious consequences for mother and infant. Uncontrolled lipid peroxidation may play an important role in the pathophysiology of preeclampsia and eclampsia by causing vascular endothelial cell dysfunction. Antioxidants serve to control lipid peroxidation. We attempted to ascertain whether antioxidant protective mechanisms are diminished in women with preeclampsia and eclampsia. MATERIALS AND METHODS:Lipid peroxidation and antioxidant markers were assayed in 25 healthy non-pregnant women as a control group, 25 third trimester normal pregnant women, 25 preeclamptic and 25 eclamptic patients of the same trimester by standard spectrophotometer methods. RESULTS: In preeclampsia and eclampsiamalondialdehyde, a product of lipid peroxidation, was significantly increased while enzymatic antioxidants like superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase were significantly reduced as compared to normal pregnant women and non-pregnant controls. CONCLUSION:Lipid peroxidation is an important factor in the pathogenesis of preeclampsia and eclampsia. The decrease in antioxidants is probably due to a compensatory nature responding to the increased lipid peroxide load in preeclamptic and eclamptic patients and may indicate the severity of the disease.
Authors: Matthew P Johnson; Shaun P Brennecke; Christine E East; Thomas D Dyer; Linda T Roten; J Michael Proffitt; Phillip E Melton; Mona H Fenstad; Tia Aalto-Viljakainen; Kaarin Mäkikallio; Seppo Heinonen; Eero Kajantie; Juha Kere; Hannele Laivuori; Rigmor Austgulen; John Blangero; Eric K Moses Journal: Mol Hum Reprod Date: 2013-02-18 Impact factor: 4.025
Authors: Ada Sandoval-Carrillo; Edna M Méndez-Hernández; Fernando Vazquez-Alaniz; Marisela Aguilar-Durán; Alfredo Téllez-Valencia; Marcelo Barraza-Salas; Francisco X Castellanos-Juárez; Osmel La Llave-León; José M Salas-Pacheco Journal: Int J Mol Sci Date: 2014-03-11 Impact factor: 5.923
Authors: Hiten D Mistry; Carolyn A Gill; Lesia O Kurlak; Paul T Seed; John E Hesketh; Catherine Méplan; Lutz Schomburg; Lucy C Chappell; Linda Morgan; Lucilla Poston Journal: Free Radic Biol Med Date: 2014-11-06 Impact factor: 7.376