Literature DB >> 196889

Effects of ACTH and diabetes on phospholipid metabolism in adrenal mitochondria.

A F De Nicola, O Fridman, V G Foglia.   

Abstract

Incorporation of 32P into adrenal mitochondrial phospholipids (PL) incrased in ACTH-treated rats, but it decreased in diabetics, inspite of the fact that these animals showed adrenal overacity. Since diabetics did not show increased 11 beta-hydroxylation. as opposed to ACTH-treated rats, it is suggested that the stimulation of this enzyme activity by exogenous ACTH is related to an increased turnover of PL at the mitochondrial membrane. The process is impaired in diabetics and prevents the stimulation of 11 beta-hydroxylation.

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Year:  1977        PMID： 196889     DOI： 10.1007/bf01951313

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Disturbances of the hypothalamo-hypophysial-adrenocortical system in the alloxan diabetic rat.

Authors:  M L'Age; J Langholz; W Fechner; H Salzmann
Journal:  Endocrinology       Date:  1974-09       Impact factor: 4.736

2.  Phospholipids of adrenal cortex mitochondria and the steroid hydroxylases: the lipid-environment of cytochrome P-450.

Authors:  H P Wang; D R Pfeiffer; T Kimura; T T Tchen
Journal:  Biochem Biophys Res Commun       Date:  1974-03-15       Impact factor: 3.575

3.  The maintenance of mitochondrial size in the rat adrenal cortex zona fasciculata by ACTH.

Authors:  J A Canick; J L Purvis
Journal:  Exp Mol Pathol       Date:  1972-02       Impact factor: 3.362

4.  Determination of the 11-beta-hydroxylase activity in microgram samples of tissue; its quantitative histological distribution in the rat adrenal, and the influence of corticotrophin.

Authors:  K Griffiths; D Glick
Journal:  J Endocrinol       Date:  1966-05       Impact factor: 4.286

5.  Carbon tetrachloride target lipids in the rat liver microsomes. Effect of cystamine administration on their pattern of labeling by 14CCl4.

Authors:  M del C Villarruel
Journal:  Biochem Biophys Res Commun       Date:  1973-09-05       Impact factor: 3.575

6.  Studies of the diabetogenic action of streptozotocin.

Authors:  A Junod; A E Lambert; L Orci; R Pictet; A E Gonet; A E Renold
Journal:  Proc Soc Exp Biol Med       Date:  1967-10

7.  Intracellular sites of lipid synthesis and the biogenesis of mitochondria.

Authors:  E A Dennis; E P Kennedy
Journal:  J Lipid Res       Date:  1972-03       Impact factor: 5.922

8.  [Effect of diethylstilbestrol on the metabolism of liver mitochondrial and microsomal phospholipids].

Authors:  J A Brignone; C M De Brignone; A O Stoppani
Journal:  Rev Soc Argent Biol       Date:  1970 Aug-Nov

9.  Determination of lipid phosphorus in the nanomolar range.

Authors:  A Chalvardjian; E Rudnicki
Journal:  Anal Biochem       Date:  1970-07       Impact factor: 3.365

10.  Effect of chronic treatment with ACTH on 11 beta-hydroxylation in rat adrenal mitochondria.

Authors:  A F De Nicola
Journal:  Acta Physiol Lat Am       Date:  1973
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