Literature DB >> 19688332

Toll-like receptors in Alzheimer's disease.

Gary E Landreth1, Erin G Reed-Geaghan.   

Abstract

Alzheimer's disease (AD) is characterized by the formation of insoluble deposits of beta-amyloid (Abeta) within the parenchyma of the brain. These deposits are associated with a robust microglia-mediated inflammatory response. Recent work has demonstrated that Toll-like receptors (TLRs) participate in this inflammatory response. This chapter reviews the mechanisms whereby TLRs contribute to the induction of a microglial inflammatory response to promote AD pathogenesis. Specifically, the involvement of CD14 and the TLRs in microglial activation is delineated. The TLR-mediated microglial response has beneficial roles in stimulating phagocytosis as well as detrimental roles in the Abeta-stimulated release of neurotoxic products.

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Year:  2009        PMID： 19688332      PMCID： PMC3032986          DOI： 10.1007/978-3-642-00549-7_8

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  89 in total

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Review 3.  Limiting inflammatory responses during activation of innate immunity.

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4.  Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

Authors:  H Yazawa; Z X Yu; Y Le; W Gong; V J Ferrans; J J Oppenheim; C C Li; J M Wang
Journal:  FASEB J       Date:  2001-11       Impact factor: 5.191

5.  Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

Authors:  Silke Walter; Maryse Letiembre; Yang Liu; Holger Heine; Botond Penke; Wenlin Hao; Barbara Bode; Nicole Manietta; Jessica Walter; Walter Schulz-Schuffer; Klaus Fassbender
Journal:  Cell Physiol Biochem       Date:  2007

Review 6.  Role of the immune system in the pathogenesis, prevention and treatment of Alzheimer's disease.

Authors:  Imrich Blasko; Beatrix Grubeck-Loebenstein
Journal:  Drugs Aging       Date:  2003       Impact factor: 3.923

7.  Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease.

Authors:  Malabendu Jana; Carlos A Palencia; Kalipada Pahan
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

8.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Authors:  A Poltorak; X He; I Smirnova; M Y Liu; C Van Huffel; X Du; D Birdwell; E Alejos; M Silva; C Galanos; M Freudenberg; P Ricciardi-Castagnoli; B Layton; B Beutler
Journal:  Science       Date:  1998-12-11       Impact factor: 47.728

9.  Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

Authors:  Zhengfan Jiang; Tak W Mak; Ganes Sen; Xiaoxia Li
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-24       Impact factor: 11.205

10.  Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin.

Authors:  Milan Fiala; Philip T Liu; Araceli Espinosa-Jeffrey; Mark J Rosenthal; George Bernard; John M Ringman; James Sayre; Laura Zhang; Justin Zaghi; Sheila Dejbakhsh; Ben Chiang; James Hui; Michelle Mahanian; Anita Baghaee; Pamela Hong; John Cashman
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-24       Impact factor: 11.205
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  71 in total

Review 1.  Microglial cell origin and phenotypes in health and disease.

Authors:  Kaoru Saijo; Christopher K Glass
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Review 2.  Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature.

Authors:  Tony Wyss-Coray; Joseph Rogers
Journal:  Cold Spring Harb Perspect Med       Date:  2012-01       Impact factor: 6.915

Review 3.  The role of inflammatory processes in Alzheimer's disease.

Authors:  G Joseph Broussard; Jennifer Mytar; Rung-chi Li; Gloria J Klapstein
Journal:  Inflammopharmacology       Date:  2012-04-26       Impact factor: 4.473

Review 4.  Inflammation in the early stages of neurodegenerative pathology.

Authors:  Preeti J Khandelwal; Alexander M Herman; Charbel E-H Moussa
Journal:  J Neuroimmunol       Date:  2011-08-05       Impact factor: 3.478

5.  Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.

Authors:  Nathaniel S Woodling; Qian Wang; Prachi G Priyam; Paul Larkin; Ju Shi; Jenny U Johansson; Irene Zagol-Ikapitte; Olivier Boutaud; Katrin I Andreasson
Journal:  J Neurosci       Date:  2014-04-23       Impact factor: 6.167

Review 6.  Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes.

Authors:  John K Hermann; Jeffrey R Capadona
Journal:  Crit Rev Biomed Eng       Date:  2018

7.  Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.

Authors:  Liraz Shmuel-Galia; Yoel Klug; Ziv Porat; Meital Charni; Batya Zarmi; Yechiel Shai
Journal:  J Biol Chem       Date:  2017-06-27       Impact factor: 5.157

Review 8.  Microglia in Alzheimer's disease.

Authors:  Heela Sarlus; Michael T Heneka
Journal:  J Clin Invest       Date:  2017-09-01       Impact factor: 14.808

Review 9.  Inflammatory mechanisms in neurodegeneration.

Authors:  Michael R Nichols; Marie-Kim St-Pierre; Ann-Christin Wendeln; Nyasha J Makoni; Lisa K Gouwens; Evan C Garrad; Mona Sohrabi; Jonas J Neher; Marie-Eve Tremblay; Colin K Combs
Journal:  J Neurochem       Date:  2019-03-27       Impact factor: 5.372

Review 10.  Inflammation, microglia, and Alzheimer's disease.

Authors:  Brent Cameron; Gary E Landreth
Journal:  Neurobiol Dis       Date:  2009-10-13       Impact factor: 5.996
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