Literature DB >> 19688294

Mylip makes an Idol turn into regulation of LDL receptor.

Dan Lindholm1, Beat C Bornhauser, Laura Korhonen.   

Abstract

High blood low-density-lipoprotein (LDL) cholesterol is a serious health problem among an increased number of patients in the Western world. Statins and other cholesterol lowering drugs have proven to be beneficial as therapy but are not optimal and show adverse effects in some patients. The LDL receptor is a crucial determinant of cholesterol metabolism in the body and amenable for drug interventions. Novel insights into the physiology of this receptor come from studies on the ubiquitination and degradation of LDL receptor by the ubiquitin ligase Mylip/Idol that is induced in cells by the nuclear receptor, LXR. This may open up new possibilities in the future to influence LDL receptor levels and cholesterol metabolism pharmacologically in various diseases.

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Year:  2009        PMID： 19688294     DOI： 10.1007/s00018-009-0127-y

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  28 in total

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Journal:  N Engl J Med       Date:  1999-08-12       Impact factor: 91.245

2.  PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E3-ligase MIR.

Authors:  Kohji Nagano; Beat C Bornhauser; Gayathri Warnasuriya; Alan Entwistle; Rainer Cramer; Dan Lindholm; Soren Naaby-Hansen
Journal:  EMBO J       Date:  2006-04-13       Impact factor: 11.598

Review 3.  Protein sensors for membrane sterols.

Authors:  Joseph L Goldstein; Russell A DeBose-Boyd; Michael S Brown
Journal:  Cell       Date:  2006-01-13       Impact factor: 41.582

Review 4.  Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

Authors:  M S Brown; J L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

Review 5.  Minireview: liver X receptor beta: emerging roles in physiology and diseases.

Authors:  Chiara Gabbi; Margaret Warner; Jan-Ake Gustafsson
Journal:  Mol Endocrinol       Date:  2008-12-12

6.  Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.

Authors:  Da-Wei Zhang; Thomas A Lagace; Rita Garuti; Zhenze Zhao; Meghan McDonald; Jay D Horton; Jonathan C Cohen; Helen H Hobbs
Journal:  J Biol Chem       Date:  2007-04-23       Impact factor: 5.157

7.  MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain.

Authors:  Beat C Bornhauser; Per-Anders Olsson; Dan Lindholm
Journal:  J Biol Chem       Date:  2003-06-24       Impact factor: 5.157

8.  Molecular basis for LDL receptor recognition by PCSK9.

Authors:  Hyock Joo Kwon; Thomas A Lagace; Markey C McNutt; Jay D Horton; Johann Deisenhofer
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-04       Impact factor: 11.205

9.  LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

Authors:  Noam Zelcer; Cynthia Hong; Rima Boyadjian; Peter Tontonoz
Journal:  Science       Date:  2009-06-11       Impact factor: 47.728

10.  LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

Authors:  Steven J Bensinger; Michelle N Bradley; Sean B Joseph; Noam Zelcer; Edith M Janssen; Mary Ann Hausner; Roger Shih; John S Parks; Peter A Edwards; Beth D Jamieson; Peter Tontonoz
Journal:  Cell       Date:  2008-07-11       Impact factor: 41.582
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  8 in total

1.  Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).

Authors:  Hai Thi Do; Timofey V Tselykh; Johanna Mäkelä; Tho Huu Ho; Vesa M Olkkonen; Beat C Bornhauser; Laura Korhonen; Noam Zelcer; Dan Lindholm
Journal:  J Biol Chem       Date:  2012-02-29       Impact factor: 5.157

2.  Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.

Authors:  S Sayols-Baixeras; I Subirana; C Lluis-Ganella; F Civeira; J Roquer; A N Do; D Absher; A Cenarro; D Muñoz; C Soriano-Tárraga; J Jiménez-Conde; J M Ordovas; M Senti; S Aslibekyan; J Marrugat; D K Arnett; R Elosua
Journal:  Hum Mol Genet       Date:  2016-10-15       Impact factor: 6.150

3.  Di'ao Xinxuekang Capsule Improves the Anti-Atherosclerotic Effect of Atorvastatin by Downregulating the SREBP2/PCSK9 Signalling Pathway.

Authors:  Jiyi Liang; Wei Li; Honglin Liu; Xiaofen Li; Chuqiao Yuan; Wenjun Zou; Liping Qu
Journal:  Front Pharmacol       Date:  2022-04-28       Impact factor: 5.988

4.  Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

Authors:  Tanja Zeller; Philipp Wild; Silke Szymczak; Maxime Rotival; Arne Schillert; Raphaele Castagne; Seraya Maouche; Marine Germain; Karl Lackner; Heidi Rossmann; Medea Eleftheriadis; Christoph R Sinning; Renate B Schnabel; Edith Lubos; Detlev Mennerich; Werner Rust; Claire Perret; Carole Proust; Viviane Nicaud; Joseph Loscalzo; Norbert Hübner; David Tregouet; Thomas Münzel; Andreas Ziegler; Laurence Tiret; Stefan Blankenberg; François Cambien
Journal:  PLoS One       Date:  2010-05-18       Impact factor: 3.240

5.  6p22.3 deletion: report of a patient with autism, severe intellectual disability and electroencephalographic anomalies.

Authors:  Daniela Di Benedetto; Giuseppa Di Vita; Corrado Romano; Mariangela Lo Giudice; Girolamo Aurelio Vitello; Marinella Zingale; Lucia Grillo; Lucia Castiglia; Sebastiano Antonino Musumeci; Marco Fichera
Journal:  Mol Cytogenet       Date:  2013-01-17       Impact factor: 2.009

6.  Partial deletion of chromosome 6p causing developmental delay and mild dysmorphisms in a child: molecular and developmental investigation and literature search.

Authors:  Nikolaos Vrachnis; Ioannis Papoulidis; Dionysios Vrachnis; Elisavet Siomou; Nikolaos Antonakopoulos; Stavroula Oikonomou; Dimitrios Zygouris; Nikolaos Loukas; Zoi Iliodromiti; Efterpi Pavlidou; Loretta Thomaidis; Emmanouil Manolakos
Journal:  Mol Cytogenet       Date:  2021-07-24       Impact factor: 2.009

7.  Association of MYLIP rs3757354 SNP and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.

Authors:  Ting-Ting Yan; Rui-Xing Yin; Qing Li; Ping Huang; Xiao-Na Zeng; Ke-Ke Huang; Dong-Feng Wu; Lynn Htet Htet Aung
Journal:  Lipids Health Dis       Date:  2012-10-29       Impact factor: 3.876

8.  The expression of myosin-regulated light chain interacting protein (MYLIP) in lung cancer and its inhibitory effects on lung carcinomas.

Authors:  Wenhui Wang; Fenqiang Li; Peiying Gan; Dongjun Su; Gengxiang Li; Lei Dang; Yuxing Peng
Journal:  Transl Cancer Res       Date:  2021-05       Impact factor: 1.241
  8 in total

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