Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The expression of tumstatin is down-regulated in renal carcinoma.

Literature DB >> 19688274

The expression of tumstatin is down-regulated in renal carcinoma.

Chun-xiao Xu¹, Xian-xi Liu, Guo-sheng Hou, Yun-fei Yan, Shi-min Chen, Wei Wang, Guang-shui Jiang, Bin Liu, Jia-xuan Xin.

Abstract

Tumstatin is the 28 kDa NC1 domain of the alpha3 chain of type IV collagen that inhibits pathological angiogenesis and suppresses endothelial cell proliferation and tumor growth. In the present paper, we expressed and purified recombinant human tumstatin protein and then prepared the anti-tumstatin polyclonal antibody. To investigate the expression of tumstatin in renal carcinoma, tumstatin protein was detected by western blotting using the prepared anti-tumstatin antibody and tumstatin mRNA levels were assayed by RT-PCR. The results showed that the expression of tumstatin gene was down-regulated in renal carcinoma tissues and cells. Our study suggests that as a novel endogenous angiogenesis inhibitor, tumstatin gene expression may be a marker for diagnosis, therapy and prognosis of renal carcinoma.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19688274 DOI： 10.1007/s11033-009-9718-9

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

27 in total

1. Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties.

Authors: Y Maeshima; P C Colorado; R Kalluri
Journal: J Biol Chem Date: 2000-08-04 Impact factor: 5.157

2. Identification of the anti-angiogenic site within vascular basement membrane-derived tumstatin.

Authors: Y Maeshima; M Manfredi; C Reimer; K A Holthaus; H Hopfer; B R Chandamuri; S Kharbanda; R Kalluri
Journal: J Biol Chem Date: 2001-02-07 Impact factor: 5.157

Review 3. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.

Authors: D Hanahan; J Folkman
Journal: Cell Date: 1996-08-09 Impact factor: 41.582

4. Seminiferous tubule basement membrane. Composition and organization of type IV collagen chains, and the linkage of alpha3(IV) and alpha5(IV) chains.

Authors: T Z Kahsai; G C Enders; S Gunwar; C Brunmark; J Wieslander; R Kalluri; J Zhou; M E Noelken; B G Hudson
Journal: J Biol Chem Date: 1997-07-04 Impact factor: 5.157

Review 5. Tumor angiogenesis: therapeutic implications.

Authors: J Folkman
Journal: N Engl J Med Date: 1971-11-18 Impact factor: 91.245

6. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis.

Authors: Yohei Maeshima; Akulapalli Sudhakar; Julie C Lively; Kohjiro Ueki; Surender Kharbanda; C Ronald Kahn; Nahum Sonenberg; Richard O Hynes; Raghu Kalluri
Journal: Science Date: 2002-01-04 Impact factor: 47.728

7. Distinct antitumor properties of a type IV collagen domain derived from basement membrane.

Authors: Y Maeshima; P C Colorado; A Torre; K A Holthaus; J A Grunkemeyer; M B Ericksen; H Hopfer; Y Xiao; I E Stillman; R Kalluri
Journal: J Biol Chem Date: 2000-07-14 Impact factor: 5.157

8. Peritumor injections of purified tumstatin delay tumor growth and lymphatic metastasis in an orthotopic oral squamous cell carcinoma model.

Authors: In-Sik Chung; Young-Ik Son; Ye Jeung Ko; Chung-Hwan Baek; Jae Keun Cho; Han-Sin Jeong
Journal: Oral Oncol Date: 2008-05-16 Impact factor: 5.337

The expression of tumstatin is down-regulated in renal carcinoma.

1. Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties.

2. Identification of the anti-angiogenic site within vascular basement membrane-derived tumstatin.

Review 3. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.

4. Seminiferous tubule basement membrane. Composition and organization of type IV collagen chains, and the linkage of alpha3(IV) and alpha5(IV) chains.

Review 5. Tumor angiogenesis: therapeutic implications.

6. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis.

7. Distinct antitumor properties of a type IV collagen domain derived from basement membrane.

8. Peritumor injections of purified tumstatin delay tumor growth and lymphatic metastasis in an orthotopic oral squamous cell carcinoma model.

Review 9. Angiogenesis in cancer, vascular, rheumatoid and other disease.

10. Angiogenesis in bladder cancer: relationship between microvessel density and tumor prognosis.

1. Pigment epithelium-derived factor plays an inhibitory role in proliferation and migration of HaCaT cells.

2. DiPhiSeq: robust comparison of expression levels on RNA-Seq data with large sample sizes.

3. Downregulation of tumstatin expression by overexpression of ornithine decarboxylase.