PURPOSE: The expression of the PIM-1 gene, which is a proto-oncogene that encodes a serine/threonine kinase, is associated with multiple cellular functions such as proliferation, differentiation, apoptosis and tumorigenesis. In particular, several studies have reported that the PIM-1 gene is associated with the development of lymphoma, leukemia and prostate cancer. Therefore, this study was conducted to evaluate the association between the single nucleotide polymorphisms in the PIM-1 gene and the risk of lung cancer occurrence in the Korean population. MATERIALS AND METHODS: To evaluate the role of the PIM-1 gene in the development of lung cancer, the genotypes of the PIM-1 gene were determined in 408 lung cancer patients and 410 normal subjects. RESULTS: We found that the T-C-T-C haplotypes of the PIM-1 gene (-1196 T>C, IVS4 +55 T>C, IVS4 +1416 T>A and +3684 C>A) were associated with an increased risk of lung cancer [adjusted odds ratio (aOR): 3.98; 95% CI: 1.24 approximately 12.75, p-value: 0.020]. In particular, these haplotypes showed an increased risk of lung cancer in males (aOR: 5.67; 95% CI: 1.32~24.30, p-value: 0.019) and smokers (aOR: 7.82; 95% CI: 1.75 approximately 34.98, p-value: 0.007). CONCLUSIONS: The present results suggest that the T-C-T-C haplotype of the PIM-1 gene could influence the risk of developing smoking-related lung cancer in the Korean population. Additional functional studies with an larger sample sized analysis are warranted to reconfirm our findings.
PURPOSE: The expression of the PIM-1 gene, which is a proto-oncogene that encodes a serine/threonine kinase, is associated with multiple cellular functions such as proliferation, differentiation, apoptosis and tumorigenesis. In particular, several studies have reported that the PIM-1 gene is associated with the development of lymphoma, leukemia and prostate cancer. Therefore, this study was conducted to evaluate the association between the single nucleotide polymorphisms in the PIM-1 gene and the risk of lung cancer occurrence in the Korean population. MATERIALS AND METHODS: To evaluate the role of the PIM-1 gene in the development of lung cancer, the genotypes of the PIM-1 gene were determined in 408 lung cancerpatients and 410 normal subjects. RESULTS: We found that the T-C-T-C haplotypes of the PIM-1 gene (-1196 T>C, IVS4 +55 T>C, IVS4 +1416 T>A and +3684 C>A) were associated with an increased risk of lung cancer [adjusted odds ratio (aOR): 3.98; 95% CI: 1.24 approximately 12.75, p-value: 0.020]. In particular, these haplotypes showed an increased risk of lung cancer in males (aOR: 5.67; 95% CI: 1.32~24.30, p-value: 0.019) and smokers (aOR: 7.82; 95% CI: 1.75 approximately 34.98, p-value: 0.007). CONCLUSIONS: The present results suggest that the T-C-T-C haplotype of the PIM-1 gene could influence the risk of developing smoking-related lung cancer in the Korean population. Additional functional studies with an larger sample sized analysis are warranted to reconfirm our findings.
Authors: Hajime Matsuzaki; Halina Loi; Shoulian Dong; Ya-Yu Tsai; Joy Fang; Jane Law; Xiaojun Di; Wei-Min Liu; Geoffrey Yang; Guoying Liu; Jing Huang; Giulia C Kennedy; Thomas B Ryder; Gregory A Marcus; P Sean Walsh; Mark D Shriver; Jennifer M Puck; Keith W Jones; Rui Mei Journal: Genome Res Date: 2004-03 Impact factor: 9.043
Authors: Yurij Ionov; Xuan Le; Brian J Tunquist; John Sweetenham; Traci Sachs; John Ryder; Thomas Johnson; Michael B Lilly; Andrew S Kraft Journal: Anticancer Res Date: 2003 Jan-Feb Impact factor: 2.480
Authors: Jae Sook Sung; Sle Gi Lo Han; Young Mi Whang; Eun Soon Shin; Jae Won Lee; Hyo Jung Lee; Jeong-Seon Ryu; In Keun Choi; Kyong Hwa Park; Jun Suk Kim; Sang Won Shin; Elizabeth K Chu; Yeul Hong Kim Journal: Lung Cancer Date: 2008-03-04 Impact factor: 5.705
Authors: Amos M Cohen; Borislava Grinblat; Hanna Bessler; Donald Kristt; Alona Kremer; Ariel Schwartz; Marisa Halperin; Sarah Shalom; Drorit Merkel; Jeremy Don Journal: Leuk Lymphoma Date: 2004-05