| Literature DB >> 19686816 |
Ying Zi Liu1, Yong Guo Cao, Jun Qing Ye, Wei Guang Wang, Ke Ji Song, Xiao Liang Wang, Chun Hua Wang, Rong Tao Li, Xu Ming Deng.
Abstract
The objective of this study was to evaluate the immunomodulatory effects of proanthocyanidin A-1 (PAA-1) from leaves of Rhododendron spiciferum (Ericaceae). In vitro tests showed that PAA-1 stimulated cell proliferation of splenocytes and peritoneal macrophages significantly enhanced the cytotoxicity of natural killer (NK) cells and increased CD4(+) and CD8(+) cell populations. PAA-1 also regulated the expression of Th1- and Th2-related cytokines. Moreover, this study showed that PAA-1 exhibited a significant effect on NBT dye reduction and lysosomal enzyme activity responses in macrophages, indicating effective phagocytic activation. These results revealed that PAA-1 exhibits immunomodulatory activity without a clear dose response. 2009 Elsevier B.V. All rights reserved.Entities:
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Year: 2009 PMID： 19686816 DOI： 10.1016/j.fitote.2009.08.005
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882