| Literature DB >> 19686689 |
Ashley M Goss1, Ying Tian, Tadasuke Tsukiyama, Ethan David Cohen, Diane Zhou, Min Min Lu, Terry P Yamaguchi, Edward E Morrisey.
Abstract
Patterning of the primitive foregut promotes appropriate organ specification along its anterior-posterior axis. However, the molecular pathways specifying foregut endoderm progenitors are poorly understood. We show here that Wnt2/2b signaling is required to specify lung endoderm progenitors within the anterior foregut. Embryos lacking Wnt2/2b expression exhibit complete lung agenesis and do not express Nkx2.1, the earliest marker of the lung endoderm. In contrast, other foregut endoderm-derived organs, including the thyroid, liver, and pancreas, are correctly specified. The phenotype observed is recapitulated by an endoderm-restricted deletion of beta-catenin, demonstrating that Wnt2/2b signaling through the canonical Wnt pathway is required to specify lung endoderm progenitors within the foregut. Moreover, activation of canonical Wnt/beta-catenin signaling results in the reprogramming of esophagus and stomach endoderm to a lung endoderm progenitor fate. Together, these data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut.Entities:
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Year: 2009 PMID： 19686689 PMCID： PMC2763331 DOI： 10.1016/j.devcel.2009.06.005
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270