| Literature DB >> 19685927 |
Charles P Allen1, Tamas Benkovics, Amanda K Turek, Tehshik P Yoon.
Abstract
We describe a new oxaziridine-mediated approach to the amination of sp(3)-hybridized C-H bonds. In the presence of a copper(II) catalyst, N-sulfonyl oxaziridines participate in efficient intramolecular cyclization reactions to afford a variety of piperidine and tetrahydroisoquinoline structures. The aminal intermediates provide a convenient functional handle for further elaboration of these structures, demonstrating the utility of this new methodology for the rapid construction of structurally complex nitrogen-containing heterocycles.Entities:
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Year: 2009 PMID： 19685927 PMCID： PMC2737076 DOI： 10.1021/ja906183g
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419