Literature DB >> 1968336

Detection of 2H-1,4-thiazine-5,6-dihydro-3-carboxylic acid (aminoethylcysteine ketimine) in the bovine brain.

M Nardini1, R M Matarese, L Pecci, A Antonucci, G Ricci, D Cavallini.   

Abstract

2H-1,4-Thiazine-5,6-dihydro-3-carboxylic acid (trivial name: aminoethylcysteine ketimine) is a cyclic sulfur-containing imino acid detected in bovine brain extracts by means of three different procedures. Gas liquid chromatography of protein-free extracts of five bovine brains revealed the presence of this compound at concentrations ranging from 2 to 3 nmol/g wet weight of tissue. The enzymatic method based on the inhibition of D-amino acid oxidase activity by aminoethylcysteine ketimine together with an high-performance liquid chromatography procedure confirm the identification and quantitations obtained with gas liquid chromatography. The discovery of this compound structurally similar to pipecolic acid opens the question of its physiological role in the central nervous system.

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Year:  1990        PMID： 1968336     DOI： 10.1016/0006-291x(90)91000-i

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Identification of new products of S-aminoethylcysteine ketimine autoxidation.

Authors:  L Pecci; F Pinnen; A Antonucci; D Cavallini
Journal:  Amino Acids       Date:  1995-09       Impact factor: 3.520

2.  An insight in the mechanism of the aminoethylcysteine ketimine autoxidation.

Authors:  L Pecci; A Antonucci; M Fontana; G Montefoschi; D Cavallini
Journal:  Amino Acids       Date:  1996-12       Impact factor: 3.520

Review 3.  Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review.

Authors:  Alberto Macone; Mario Fontana; Marco Barba; Bruno Botta; Mirella Nardini; Francesca Ghirga; Andrea Calcaterra; Laura Pecci; Rosa Marina Matarese
Journal:  Int J Mol Sci       Date:  2011-05-12       Impact factor: 5.923

Review 4.  Imine reductases: a comparison of glutamate dehydrogenase to ketimine reductases in the brain.

Authors:  André Hallen; Joanne F Jamie; Arthur J L Cooper
Journal:  Neurochem Res       Date:  2013-01-12       Impact factor: 3.996

5.  The oxidation of sulfur containing cyclic ketimines The sulfoxide is the main product of S-aminoethyl-cysteine ketimine autoxidation.

Authors:  L Pecci; S P Solinas; A Antonucci; G Montefoschi; C Blarzino; D Cavallini
Journal:  Amino Acids       Date:  1993-02       Impact factor: 3.520

6.  Stable isotope gas chromatography-tandem mass spectrometry determination of aminoethylcysteine ketimine decarboxylated dimer in biological samples.

Authors:  Dimitrios Tsikas; Christopher E Evans; Travis T Denton; Anja Mitschke; Frank-Mathias Gutzki; John T Pinto; Tetyana Khomenko; Sandor Szabo; Arthur J L Cooper
Journal:  Anal Biochem       Date:  2012-07-31       Impact factor: 3.365

Review 7.  An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues.

Authors:  Dunxin Shen; Kenneth Hensley; Travis T Denton
Journal:  Anal Biochem       Date:  2019-12-17       Impact factor: 3.365

8.  Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism.

Authors:  John T Pinto; Tetyana Khomenko; Sandor Szabo; Gordon D McLaren; Travis T Denton; Boris F Krasnikov; Thomas M Jeitner; Arthur J L Cooper
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2009-05-28       Impact factor: 3.205

Review 9.  Chemistry and Biochemistry of Sulfur Natural Compounds: Key Intermediates of Metabolism and Redox Biology.

Authors:  Antonio Francioso; Alessia Baseggio Conrado; Luciana Mosca; Mario Fontana
Journal:  Oxid Med Cell Longev       Date:  2020-09-29       Impact factor: 6.543
  9 in total

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